5406-21-3

Basic information

• Product Name: 2-{[(3-CHLOROPHENYL)AMINO]CARBONYL}-BENZOIC ACID
• Synonyms: 2-[(3-chlorophenyl)carbamoyl]benzoic acid;N-(3-Chloro-phenyl)-phthalamic acid
• CAS NO: 5406-21-3
• Molecular Formula: C₁₄H₁₀ClNO₃
• Molecular Weight: 275.69
• Mol File: 5406-21-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 383.2°Cat760mmHg
• Flash Point: 185.5°C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 1.48E-06mmHg at 25°C
• Refractive Index: 1.677
• CAS DataBase Reference: 2-{[(3-CHLOROPHENYL)AMINO]CARBONYL}-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(3-CHLOROPHENYL)AMINO]CARBONYL}-BENZOIC ACID(5406-21-3)
• EPA Substance Registry System: 2-{[(3-CHLOROPHENYL)AMINO]CARBONYL}-BENZOIC ACID(5406-21-3)

Safety Data

• Hazardous Substances Data: 5406-21-3(Hazardous Substances Data)

Usage

General Description

The chemical 2-{[(3-chlorophenyl)amino]carbonyl}-benzoic acid is a compound with the molecular formula C14H10ClNO3. It is an organic compound that contains a benzoic acid group and a chlorophenyl group connected to an amino carbonyl group. This chemical is often used as a building block in the synthesis of pharmaceuticals and other organic compounds. It is important to handle this chemical with care as it may pose health hazards if not used properly.

InChI:InChI=1/C14H10ClNO3/c15-9-4-3-5-10(8-9)16-13(17)11-6-1-2-7-12(11)14(18)19/h1-8H,(H,16,17)(H,18,19)

Upstream product

• 85-44-9 phthalic anhydride 
• 108-42-9 3-chloro-aniline 

Downstream Products

• 16082-71-6 N-(3-chlorophenyl)phthalimide 

Relevant articles and documents

Microwave assisted synthesis of N-Arylphthalamic acids with hyperlipidemic activity

A series of substituted N-arylphthalamic acids 3a-i has been synthesized by the reaction of phthalic anhydride 1 and aryl- or heterocyclic amines 2a-i, in the absence of solvents, in a domestic microwave oven. The formation of nine N-arylphthalamic acids was accomplished in 1-3 min giving excellent yields for compounds 3a-g, but moderate yield of compounds 3h and 3i, respectively. Compounds 3h and 3i are new. Interestingly, N-arylphthalamic acids 3a-i induced hyperlipidemia in Swiss white mice and also increased animals' body weight.

Reaction of cyclic anhydrides with aromatic amines: Part I - Synthesis of anilinic acids from phthalic anhydride

Some unreported anilinic acids 5a-j and 7 have been synthesised and their spectral data reported. Their in vitro insecticidal screening as protectants of maize (Zea mays) against Sitophilus zeamais shows 2-(N-naphthylcarbamoyl)benzoic acid 7 to be the most active member of the series.