5410-78-6

Basic information

• Product Name: 4-aminophenyldichloroarsine
• Synonyms: 4-aminophenyldichloroarsine;(4-AMinophenyl)arsonous Dichloride Monohydrochloride
• CAS NO: 5410-78-6
• Molecular Formula: C₆H₆AsCl₂N*ClH
• Molecular Weight: 274.41
• Product Categories: Amines;Aromatics;MTS & Sulfhydryl Active Reagents
• Mol File: 5410-78-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 329.8°Cat760mmHg
• Flash Point: 153.3°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.000173mmHg at 25°C
• CAS DataBase Reference: 4-aminophenyldichloroarsine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-aminophenyldichloroarsine(5410-78-6)
• EPA Substance Registry System: 4-aminophenyldichloroarsine(5410-78-6)

Safety Data

• Hazardous Substances Data: 5410-78-6(Hazardous Substances Data)

Usage

Description

4-aminophenyldichloroarsine is an organoarsenic compound that has found applications in various fields due to its unique chemical properties. It is characterized by the presence of an amino group attached to a phenyl ring, with two chlorine atoms also bonded to the arsenic atom. This structure endows it with specific reactivity and utility in certain chemical and biological processes.

Uses

Used in Research Applications:
4-aminophenyldichloroarsine is used as a reagent for the study of 2-oxoacid dehydrogenase multienzyme complexes. Its application in this field is due to its ability to interact with and modulate the activity of these complexes, which are crucial for cellular metabolism and energy production.
In the field of biochemistry and molecular biology, 4-aminophenyldichloroarsine serves as a valuable tool for understanding the structure, function, and regulation of 2-oxoacid dehydrogenase multienzyme complexes. These complexes play a significant role in the metabolism of carbohydrates, fats, and amino acids, making them an important area of study for various diseases and conditions related to metabolism.
Additionally, 4-aminophenyldichloroarsine may have potential applications in other industries, such as pharmaceuticals or materials science, where its unique chemical properties could be harnessed for specific purposes. However, further research and development would be required to explore these possibilities and determine the safety and efficacy of its use in these contexts.

Safety Profile

Poison by intravenous route. When heated to decomposition it emits toxic fumes of NO,, As, Cl-, and HCl

InChI:InChI=1/C6H6AsCl2N/c8-7(9)5-1-3-6(10)4-2-5/h1-4H,10H2

Upstream product

• 98-50-0 p-aminophenylarsonic acid 

Downstream Products

• 1122-90-3 4-aminophenylarsenoxide 
• 62-53-3 aniline 
• 1613402-21-3 C₂₇H₂₈AsN₃O₃S₂ 
• 5577-20-8 4-(1,3,2-dithiocycloarsenic-2-yl)aniline 
• 1613402-18-8 2-(4-acetamidophenyl)-1,3,2-dithiarsinane 

Relevant articles and documents

Thiourea-containing arsenic sugar with anti-tumor activity and preparation method and application thereof

The invention relates to the field of arsenic sugar, and in particular relates to thiourea-containing arsenic sugar with anti-tumor activity and a preparation method and application thereof. The thiourea-containing arsenic sugar is composed of two compounds: 1-(N-(4'-(1'', 3'', 2''-dithiaarsenic pentane-2-yl) phenyl)-thiourea)-2, 3, 4, 6-O-acetyl-beta-D-glucose and 1-(N-(4'-(1'', 3 '', 2''-dithiaarsenic hexane-2-yl) phenyl)-thiourea)-2, 3, 4, 6-O-acetyl-beta-D-glucose. The thiourea-containing arsenic sugar provided by the invention has the advantages of simple reaction operation and high yield. The thiourea-containing arsenic sugar with a specific three-dimensional configuration can be obtained, and the thiourea-containing arsenic sugar has good anti-tumor activity.

Carbohydrate-conjugated 4-(1,3,2-dithiarsolan-2-yl)aniline as a cytotoxic agent against colorectal cancer

Arsenic trioxide (As2O3) has been approved for the treatment of acute promyelocytic leukemia (APL); however, its use in the treatment of solid tumors is limited due to its pharmacokinetic properties. Organic arsenic compounds provide better options for pharmaceutical optimization. p-Aminophenyl arsenoxide (p-APAO), an organic arsenic compound, was found to interact with the promyelocytic leukemia-retinoic acid receptor alpha (PML-RARα) fusion protein in a similar manner to arsenic trioxide. Analogs of p-APAO such as 4-(1,3,2-dithiarsolan-2-yl)aniline (p-APDTAs) were recently found to show improved cytotoxicity toward several solid tumor cell lines with lower toxicity to normal cells. Here, we synthesized a carbohydrate-conjugated 4-(1,3,2-dithiarsolan-2-yl)aniline (p-APDTAs) and showed that it exhibited reduced cytotoxicity to normal cells, suggesting a feasible approach to improve the therapeutic index of arsenic-containing compounds as chemotherapeutic agents.

Synthesis of a novel C3-symmetric arsine and its application in stereoselective cyclopropanation of electron-deficient olefins

A novel C3-symmetric arsine was synthesized from p-arsanilic acid in three steps. It was employed in the one-pot cyclopropanation of olefins with carbonyl-stabilized arsonium ylides formed in situ from methyl bromoacetate in the presence of NaH