5411-61-0

Basic information

• Product Name: 4-Bromo-7-methoxy-indan-1-one
• Synonyms: 4-Bromo-7-methoxy-indan-1-one;4-Bromo-2,3-dihydro-7-methoxy-1H-inden-1-one;NSC 10995;4-broMo-7-Methoxy-2,3-dihydro-1H-inden-1-one;1H-Inden-1-one, 4-broMo-2,3-dihydro-7-Methoxy-;4-Bromo-7-methoxy-1-indanone;4-Bromo-7-methoxyindanone;4-bromo-7-methoxy-2,3-dihydroinden-1-one
• CAS NO: 5411-61-0
• Molecular Formula: C₁₀H₉BrO₂
• Molecular Weight: 241.083
• Mol File: 5411-61-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 134-135℃
• Boiling Point: 369℃
• Flash Point: 177℃
• Appearance: /
• Density: 1.553
• Vapor Pressure: 1.24E-05mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Bromo-7-methoxy-indan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-7-methoxy-indan-1-one(5411-61-0)
• EPA Substance Registry System: 4-Bromo-7-methoxy-indan-1-one(5411-61-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 5411-61-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 2965, 1950 DOI: 10.1021/ja01163a042

InChI:InChI=1/C10H9BrO2/c1-13-9-5-3-7(11)6-2-4-8(12)10(6)9/h3,5H,2,4H2,1H3

Upstream product

• 66192-02-7 3-(2-bromo-5-methoxyphenyl)propanoic acid 
• 125714-97-8 4,6-dibromo-7-methoxy-2,3-dihydro-1H-inden-1-one 
• 108-18-9 diisopropylamine 
• 77-78-1 dimethyl sulfate 
• 10516-71-9 3-(3-Methoxy-phenyl)-propionic acid 
• 6968-35-0 7-hydroxy-indan-1-one 
• 5456-94-0 2,4-dibromo-5-methylanisole 
• 6520-93-0 3-(2',4'-Dibrom-5'-methoxyphenyl)propionsaeure 
• 125714-92-3 2,4-Dibrom-5-methoxybenzylbromid 
• 101819-41-4 4,6-dibromo-7-hydroxy-2,3-dihydro-1H-inden-1-one 
• 125714-96-7 (2',4'-Dibrom-5'-methoxybenzyl)malonsaeure 
• 125734-68-1 (2,4-Dibrom-5-methoxybenzyl)malonsaeure-diethylester 
• 621-54-5 3-(3-hydroxyphenyl)-propanoic acid 
• 6099-04-3 3-methoxycinnamic acid 

Downstream Products

• 135064-20-9 cis-5-methoxy-2-propyl-2,3,4,4a,9,9a-hexahydro-1H-indeno<2,1-c>pyridine 
• 135064-20-9 trans-5-methoxy-2-propyl-2,3,4,4a,9,9a-hexahydro-1H-indeno<2,1-c>pyridine 
• 74904-29-3 8-methoxy-3,4-dihydroisoquinolin-1(2H)-one 

Relevant articles and documents

Grob-Type Fragmentation Releases Paracyclophane Ring Strain in a Late-Stage Precursor of Haouamine A

A ketene [2 + 2]-addition, an intramolecular aldol reaction, a Suzuki-Miyaura coupling, and a chemoselective lactam reduction were used to prepare a late-stage precursor of haouamine A. Exposure to acid led to a Grob-type fragmentation of the strained 3-aza[7]paracyclophane ring, followed by a tandem Pictet-Spengler reaction of the intermediate iminium ion and conversion to a novel 1,4a-propanocyclopenta[b]pyridine. This cascade reaction might also be relevant for the mechanism of action of the natural product.

CYCLIC AMINE DERIVATIVE OR SALT THEREOF

Provided are compounds which are an NMDA antagonist having a broad safety margin and are useful as a treating agent or a preventing agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, pain, etc. Concretely prov

Synthesis and structure activity relationships of cis- and trans- 2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines for 5-HT receptor subtypes

A series of cis- and trans-fused hexahydroindeno[2,1-c]pyridines have been prepared and evaluated for affinity and selectivity at the 5-HT(1A) subtype of the serotonin receptor. Using molecular modeling studies we predicted that the 5-methoxy-trans-fused