54117-37-2Relevant articles and documents
Design, synthesis and evaluation of carbazole derivatives as potential antimicrobial agents
Xue, Yi-Jie,Li, Ming-Yue,Jin, Xue-Jun,Zheng, Chang-Ji,Piao, Hu-Ri
, p. 295 - 306 (2021/01/13)
Five series of novel carbazole derivatives containing an aminoguanidine, dihydrotriazine, thiosemicarbazide, semicarbazide or isonicotinic moiety were designed, synthesised and evaluated for their antimicrobial activities. Most of the compounds exhibited potent inhibitory activities towards different bacterial strains (including one multidrug-resistant clinical isolate) and one fungal strain with minimum inhibitory concentrations (MICs) between 0.5 and 16 μg/ml. Compounds 8f and 9d showed the most potent inhibitory activities (MICs of 0.5–2 μg/ml). Furthermore, compounds 8b, 8d, 8f, 8k, 9b and 9e with antimicrobial activities were not cytotoxic to human gastric cancer cell lines (SGC-7901 and AGS) or a normal human liver cell line (L-02). Structure–activity relationship analyses and docking studies implicated the dihydrotriazine group in increasing the antimicrobial potency and reducing the toxicity of the carbazole compounds. In vitro enzyme activity assays suggested that compound 8f binding to dihydrofolate reductase might account for the antimicrobial effect.
Synthesis and biological evaluation of novel carbazole-rhodanine conjugates as topoisomerase II inhibitors
Jiang, Hong,Zhang, Wen-Jin,Li, Peng-Hui,Wang, Jian,Dong, Chang-Zhi,Zhang, Kun,Chen, Hui-Xiong,Du, Zhi-Yun
, p. 1320 - 1323 (2018/03/21)
In this study, a series of carbazole-rhodanine conjugates was synthesized and evaluated for their Topoisomerase II inhibition potency as well as cytotoxicity against a panel of four human cancer cell lines. Among these thirteen compounds, 3a, 3b, 3g, and
Azahelicenes as visible light photoinitiators for cationic and radical polymerization: Preparation of photoluminescent polymers and use in high performance LED projector 3D printing resins
Al Mousawi, Assi,Dumur, Frédéric,Garra, Patxi,Toufaily, Joumana,Hamieh, Tayssir,Goubard, Fabrice,Bui, Thanh-Tuan,Graff, Bernadette,Gigmes, Didier,Pierre Fouassier, Jean,Lalevée, Jacques
, p. 1189 - 1199 (2017/03/05)
In this article, novel azahelicenes (AZs) were synthesized and proposed as high performance visible light photoinitiators for both the free radical polymerization of acrylates and the cationic polymerization (CP) of epoxides upon visible light exposure us