54130-36-8 Usage
Description
N-ETHYL-9ALPHA, 11ALPHA, 15S-TRIHYDROXY-PROSTA-5Z, 13E-DIEN-1-AMIDE, also known as Prostaglandin F2α ethyl amide (PGF2α-NEt), is a modified analog of Prostaglandin F2α (PGF2α) with an N-ethyl amide group at the C-1 carboxyl position. This modification enhances its ocular hypotensive activity, making it a promising candidate for the treatment of glaucoma and other ocular hypertension conditions. PGF2α-NEt is expected to exhibit the typical intraocular effects of PGF2α free acid but with slower hydrolysis pharmacokinetics due to the N-amides structure.
Uses
Used in Ophthalmology:
PGF2α-NEt is used as an ocular hypotensive agent for the treatment of glaucoma and ocular hypertension. Its application reason is based on its ability to reduce intraocular pressure by enhancing uveoscleral and trabecular outflow, which is crucial in managing these eye conditions.
Used in Pharmaceutical Research:
PGF2α-NEt serves as a valuable compound in pharmaceutical research, particularly in the development of novel drug delivery systems and prodrugs. Its unique structure allows for a slower hydrolysis rate, which can be beneficial in designing more effective and long-lasting treatments for various ocular conditions.
Used in Drug Development:
In the drug development industry, PGF2α-NEt is used as a starting point for the creation of new prostaglandin-based medications. Its modified structure provides a foundation for further chemical modifications and optimization, potentially leading to improved pharmacological properties and therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 54130-36-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,1,3 and 0 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 54130-36:
(7*5)+(6*4)+(5*1)+(4*3)+(3*0)+(2*3)+(1*6)=88
88 % 10 = 8
So 54130-36-8 is a valid CAS Registry Number.
