54135-82-9

Basic information

• Product Name: 1,2,3-trichloro-5-methoxybenzene
• Synonyms: 3,4,5-Trichloroanisole; benzene, 1,2,3-trichloro-5-methoxy-; methyl 3,4,5-trichlorophenyl ether
• CAS NO: 54135-82-9
• Molecular Formula: C₇H₅Cl₃O
• Molecular Weight: 211.473
• Mol File: 54135-82-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 264.3°C at 760 mmHg
• Flash Point: 106.2°C
• Density: 1.416g/cm³
• Vapor Pressure: 0.0161mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 1,2,3-trichloro-5-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3-trichloro-5-methoxybenzene(54135-82-9)
• EPA Substance Registry System: 1,2,3-trichloro-5-methoxybenzene(54135-82-9)

Safety Data

• Hazardous Substances Data: 54135-82-9(Hazardous Substances Data)

Usage

Type of compound

Chlorinated derivative of methoxybenzene

Applications

a. Synthesis of pharmaceuticals
b. Synthesis of agrochemicals
c. Production of fungicides, insecticides, and herbicides

Usage

Intermediate in the production of various pesticides

Physical state

White to off-white solid at room temperature

Molecular weight

207.47 g/mol

Agricultural use

Control of pests and protection of crops

Pesticide properties

Potent pesticide properties for agricultural industry

Upstream product

• 33719-74-3 3,5-dichloroanisole 
• 64-17-5 ethanol 
• 7664-93-9 sulfuric acid 
• 54300-74-2 2,3,4-trichloro-6-methoxyaniline 
• 591-35-5 3,5-dichlorophenol 

Downstream Products

• 609-19-8 3,4,5-trichlorophenol 
• 151143-59-8 2-nitro-3,4,5-trichloroanisole 
• 54300-74-2 2,3,4-trichloro-6-methoxyaniline 
• 155499-03-9 1-(2,3,4-trichloro-6-methoxyphenyl)-1H-pyrrole 
• 155499-04-0 2-bromo-1-(2,3,4-trichloro-6-methoxyphenyl)-1H-pyrrole 
• 131956-35-9 2,3-dichloro-1-(2,3,4-trichloro-6-methoxyphenyl)-1H-pyrrole 
• 155499-05-1 1-(2,3,4-trichloro-6-methoxyphenyl)-1H-pyrrole-2-carboxylic acid 
• 155499-06-2 4,5-dichloro-1-(2,3,4-trichloro-6-methoxyphenyl)-1H-pyrrole-2-carboxylic acid 
• 155499-11-9 (+/-)-neopyrrolomycin 
• 155589-89-2 3-chloro-1-(2,3,4-trichloro-6-methoxyphenyl)-1H-pyrrole 
• 155589-88-1 2-chloro-1-(2,3,4-trichloro-6-methoxyphenyl)-1H-pyrrole 
• 155589-86-9 1-(2,3,4-trichloro-6-methoxyphenyl)-2-iodo-1H-pyrrole 
• 155589-90-5 2,5-dichloro-1-(2,3,4-trichloro-6-methoxyphenyl)-1H-pyrrole 

Relevant articles and documents

Total synthesis of (+)- and (-)-neopyrrolomycins, chlorinated phenylpyrrole antibiotics

The first total synthesis of (+)- and (-)-neopyrrolomycins (11a and 11b) is detailed based on regioselective chlorinations of 3,5-dichloroanisole (2) and 1-(2,3,4-trichloro-6-methoxyphenyl)-1H-pyrrole-2-carboxylic acid (8) with isocyanuric trichloride, followed by optical resolution of racemic neopyrrolomycin (11) with N-(p-tolylsulfonyl)-L-phenylalanyl chloride. Several analogs (21-25) have been prepared from the intermediates, and the structure-activity relationships are also discussed.

Total Synthesis of Chlorinated Phenylpyrrole Antibiotics, (+)- and (-)-Neopyrrolomycins

(+)- and (-)-Neopyrrolomycins have been synthesized from 3,5-dichlorophenol through regioselective halogenations and optical resolution.