54191-04-7

Basic information

• Product Name: cyproheptadine 10,11-epoxide
• Synonyms: cyproheptadine 10,11-epoxide;6-(1-Methylpiperidin-4-ylidene)-1a,10b-dihydro-6H-dibenzo[3,4:6,7]cyclohept[1,2-b]oxirene;Cycloheptadine 10,11-oxide
• CAS NO: 54191-04-7
• Molecular Formula: C21H21NO
• Molecular Weight: 303.403
• Mol File: 54191-04-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 480.2°Cat760mmHg
• Flash Point: 139.5°C
• Appearance: /
• Density: 1.194g/cm³
• Vapor Pressure: 2.21E-09mmHg at 25°C
• Refractive Index: 1.641
• PKA: 8.93±0.20(Predicted)
• CAS DataBase Reference: cyproheptadine 10,11-epoxide(CAS DataBase Reference)
• NIST Chemistry Reference: cyproheptadine 10,11-epoxide(54191-04-7)
• EPA Substance Registry System: cyproheptadine 10,11-epoxide(54191-04-7)

Safety Data

• Hazardous Substances Data: 54191-04-7(Hazardous Substances Data)

Usage

Description

Cyproheptadine 10,11-epoxide is an impurity derived from Cyproheptadine, which is a first-generation antihistamine. It possesses anticholinergic, antiserotonergic, and local anesthetic properties. Cyproheptadine is known for its antagonistic action on 5-HT2/5-HT1C serotonin receptors and H1 histamine receptors, making it an effective antipruritic agent.

Uses

Used in Pharmaceutical Industry:
Cyproheptadine 10,11-epoxide is used as an impurity in the production of Cyproheptadine, a first-generation antihistamine. It is utilized for its anticholinergic, antiserotonergic, and local anesthetic properties, which contribute to the overall effectiveness of Cyproheptadine in treating various conditions such as allergies, itching, and other histamine-related issues.
Used in Research and Development:
Cyproheptadine 10,11-epoxide can be used as a research compound for studying the effects and mechanisms of action of Cyproheptadine. This can help in understanding the drug's interactions with serotonin and histamine receptors, as well as its potential applications in the development of new medications with similar or improved properties.
Used in Quality Control and Regulatory Compliance:
Cyproheptadine 10,11-epoxide is used in the quality control and regulatory compliance processes for Cyproheptadine. By monitoring the levels of this impurity, manufacturers can ensure the safety, efficacy, and consistency of the final product, adhering to industry standards and regulations.

InChI:InChI=1/C21H21NO/c1-22-12-10-14(11-13-22)19-15-6-2-4-8-17(15)20-21(23-20)18-9-5-3-7-16(18)19/h2-9,20-21H,10-13H2,1H3

Upstream product

• 129-03-3 cyproheptadine 
• 969-33-5 cyproheptadine hydrochloride 

Relevant articles and documents

Identification of desmethylcyproheptadine 10,11 epoxide and other cyproheptadine metabolites isolated from rat urine

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