54198-81-1

Basic information

• Product Name: Pyrimidine, 4-(chloromethyl)- (9CI)
• Synonyms: Pyrimidine, 4-(chloromethyl)- (9CI);PyriMidine, 4-(chloroMethyl)-;4-pyriMidinylMethyl chloride
• CAS NO: 54198-81-1
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.5596
• Product Categories: PYRIMIDINE
• Mol File: 54198-81-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 219℃
• Flash Point: 107℃
• Appearance: /
• Density: 1.241
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: Pyrimidine, 4-(chloromethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 4-(chloromethyl)- (9CI)(54198-81-1)
• EPA Substance Registry System: Pyrimidine, 4-(chloromethyl)- (9CI)(54198-81-1)

Safety Data

• Hazardous Substances Data: 54198-81-1(Hazardous Substances Data)

Usage

General Description

Pyrimidine, 4-(chloromethyl)- (9CI) is a chemical compound with the molecular formula C5H5ClN2. It is a derivative of pyrimidine, a heterocyclic aromatic organic compound. The addition of a chloromethyl group to the pyrimidine ring gives the compound potential reactivity and utility in organic synthesis. It may be used as a building block in the creation of more complex chemical structures and may have applications in the pharmaceutical or agrochemical industries. It is important to handle this compound with care, as it is likely to be toxic and potentially hazardous if not used properly.

Upstream product

• 3438-46-8 4-Methylpyrimidine 
• 33342-83-5 6-methylpyrimidine 1-oxide 
• 94-36-0 dibenzoyl peroxide 

Downstream Products

• 119395-99-2 dilithium S-(4-methylpyrimidine)phosphorothioate 
• 119979-37-2 4-thiomethylpyrimidine 
• 1163765-03-4 N-(2-fluoro-4-iodo-phenyl)-2-pyrimidin-4-ylmethyl-malonamic acid ethyl ester 
• 1163765-11-4 N-(2-fluoro-4-methylsulfanyl-phenyl)-2-pyrimidin-4-ylmethyl-malonamic acid methyl ester 
• 794522-90-0 2-(pyrimidin-4-yl)acetonitrile 

Relevant articles and documents

FTO INHIBITORS

The invention provides compounds that inhibit FTO (fat mass and obesity), including pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof, particularly obesity, with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

AGONISTS OF THE APELIN RECEPTOR AND METHODS OF USE THEREOF

Provided herein are small molecule agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions.

Stereoselective synthesis of 12,13-cyclopropyl-epothilone B and side-chain-modified variants

A general strategy has been devised for the stereoselective synthesis of 12,13-cyclopropyl-epothilone B and side-chain-modified variants thereof, which relies on late stage introduction of the heterocycle through Wittig olefination of ketone 14. Formation of the macrocycle was achieved through RCM-based ring closure and introduction of the cyclopropane moiety involved a highly selective Charette cyclopropanation of allylic alcohol 7.