54201-84-2

Basic information

• Product Name: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol
• Synonyms: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol;17-Hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione cyclic bis(1,2-ethanediyl acetal);3,3,20,20-Bis(ethylene-dioxy)-17α-hydroxy-19-norpregna-5(10),9(11)-diene;3,3,20,20-bis(ehtylene-dioxy)-17a-hydroxy-19-norpregna-5(10),9(11)-diene;19-Norpregna-5(10),9(11)-diene-3,20-dione,17-hydroxy-, cyclic 3,20-bis(1,2-ethanediyl acetal), (5a,10a)-;3,3,20,20-Bis(ethylene-dioxy)-17α-hydroxy-19/;17-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione 3,20-bis(ethylene acetal);3,20-BIS(ETHYLENEDIOXY)-19-NORPREGNA-5(10),9(11)-DIENE-17-OL
• CAS NO: 54201-84-2
• Molecular Formula: C₂₄H₃₄O₅
• Molecular Weight: 402.52376
• EINECS: 1308068-626-2
• Product Categories: API
• Mol File: 54201-84-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 568 °C at 760 mmHg
• Flash Point: 297.3 °C
• Appearance: /
• Density: 1.25
• PKA: 14.95±0.40(Predicted)
• CAS DataBase Reference: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol(54201-84-2)
• EPA Substance Registry System: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol(54201-84-2)

Safety Data

• Hazardous Substances Data: 54201-84-2(Hazardous Substances Data)

Usage

General Description

3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol is a synthetic compound with a complex chemical structure. It belongs to the class of steroids and is specifically a norpregnane derivative. The compound contains two ethylenedioxy groups and a hydroxyl group, and its molecular formula is C25H32O4. It is often used in the field of medicinal chemistry and pharmaceutical research for its potential biological activities, especially in relation to hormone receptors and related pathways. The compound may have potential applications in the development of new drugs for hormone-related conditions and diseases.

Upstream product

• 107-21-1 ethylene glycol 
• 596-61-2 17α-19-Dihydroxy-progesteron 
• 5251-19-4 17α-Hydroxy-19-nor-pregnen-(5(10))-dion-(3,20) 
• 510-64-5 3,17-Dioxo-13-methyl-10-hydroxymethyl-1,2,3,6,7,8,9,10,11,12,13,14,15,16-tetradekahydro-17H-cyclopentaphenanthren 
• 42982-49-0 3,3-[1,2-ethanediylbis(oxy)]-17α-hydroxy-19-norpregna-5(10),9(11)-diene-20-one 
• 290825-36-4 3,3-ethylenedioxy-17β-cyano-17α-chloromethyl(dimethyl)siloxy estren-5(10),9(11)diene 
• 5571-36-8 ethylene deltenone 
• 14340-01-3 17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione 

Downstream Products

• 54201-83-1 5α,10α-epoxy-17α-hydroxy-19-norpregn-9(11)-ene-3,20-dione 3,20-bis(ethylene acetal) 
• 159811-51-5 CDB-3236 
• 126690-41-3 3,3,20,20-bis(ethylene-dioxy)-5α-17α-dihydroxy-11β-[4-(N,N-dimethylamino)-phenyl-]-19-norpregna-9(11)-ene 
• 159681-67-1 11β-(4-N-methylaminophenyl)-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione 
• 244206-52-8 11β-(4-aminophenyl)-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione 
• 244206-56-2 17α-acetoxy-11β-(4-N-acetyl-N-methylaminophenyl)-19-norpregna-4,9-diene-3,20-dione 
• 244206-53-9 11β-(4-N-trifluoroacetamidophenyl)-17α-acetoxy-19-norpregna-4,9-diene-3,20-dione 
• 244206-51-7 3,20-bis-ethylenedioxy-5α,17α-dihydroxy-11β-(4-aminophenyl)-19-norpregn-9-ene 
• 244206-54-0 C₃₄H₅₁NO₆Si 
• 14340-01-3 17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione 
• 54201-83-1 C₂₄H₃₄O₆ 
• 25092-42-6 (11β,17α)-17-hydroxy-11-methyl-norpregna-4-en-3,20-dione 

Relevant articles and documents

Environmentally-friendly synthesis method of ulipristal acetate intermediate and ulipristal acetate

The invention provides a method for environmentally-friendly synthesis of an ulipristal acetate intermediate and ulipristal acetate. According to the invention, a compound 2 is used as a starting rawmaterial, and reacts with acetylene in a solvent to form an alkynyl alcohol compound intermediate 3, a hydration reaction is performed with water under the catalysis of an ionic liquid and CO2 to obtain an intermediate 4, the intermediate 4 is subjected to carbonyl protection to obtain an intermediate 5, and the intermediate 5 is subjected to double bond epoxidation, a Grignard reaction, decarbonylation protection and acetylation to obtain the high-purity ulipristal acetate. The method is environment-friendly, convenient in steps, mild in conditions, low in cost, easy to amplify and suitable for industrial production, and the solvent can be recycled.

Cyclic utilization method of sterides epoxy isomer

The invention provides a cyclic utilization method of sterides epoxy isomer. Biphenyl organic solvent is reacted with active metal lithium, sodium, and potassium, and others, and reduced to be conjugated double bond; under the alkali environment, the ketal protection radical group is not influenced, and 17- hydroxyl is also not influenced, thus the position of double bond is not changed and doublebonds are directly transformed to be raw material of the last step, and the raw materials are recycled. The method adopts one-step reduction, and solves the existing common technique of opening loopof epoxy bond firstly and then dewatering to be double bonds, and avoids that the ketal protection radical can be damaged by directly reducing epoxy bond to be double bonds by metal in the alkali environment; the epoxy isomer beta and a part of alpha isomer are directly reduced to be the raw material containing conjugated double bond in last step, thus a simple cycle is realized.

Preparation method of ulipristal acetate diketal

The invention discloses a preparation method of ulipristal acetate diketal. Dihydroxyprogesterone dehydrogenate 1 is used as the raw material to prepare an important intermediate of sterides, namely ulipristal acetate diketal 8; a reaction formula is shown in the attached figure. The preparation method has the advantages that the dihydroxyprogesterone dehydrogenate 1 is used as a starting raw material, seven steps are performed, and the ulipristal acetate diketal with weight total yield rate of 65% or above can be obtained; the reaction is simple, the selectivity is good, and the preparation method is suitable for industrialization production.