5422-47-9

Basic information

• Product Name: 1-(4-methoxyphenyl)-2-phenylethanol
• CAS NO: 5422-47-9
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.2863
• Mol File: 5422-47-9.mol
• Article Data: 32

Chemical Properties

• Boiling Point: 354.3°C at 760 mmHg
• Flash Point: 152.7°C
• Density: 1.112g/cm³
• Vapor Pressure: 1.24E-05mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 1-(4-methoxyphenyl)-2-phenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-2-phenylethanol(5422-47-9)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-2-phenylethanol(5422-47-9)

Safety Data

• Hazardous Substances Data: 5422-47-9(Hazardous Substances Data)

Usage

Description

1-(4-methoxyphenyl)-2-phenylethanol, also known as p-methoxyphenyl-phenylethanol or PMPOH, is a chemical compound that belongs to the family of phenylethanolamines. It is a colorless to pale yellow liquid with a floral, rose-like odor and is recognized for its antioxidant and antimicrobial properties. PMPOH is generally considered to have low toxicity, but it is essential to follow proper handling and storage procedures for safe use.

Uses

Used in Fragrance Industry:
1-(4-methoxyphenyl)-2-phenylethanol is used as a fragrance ingredient for its pleasant floral, rose-like aroma. It is widely utilized in the production of perfumes, soaps, and cosmetics to enhance their scent profiles.
Used in Food Industry:
In the food industry, 1-(4-methoxyphenyl)-2-phenylethanol is used as a flavoring agent to impart a unique and appealing taste to various food products.
Used in Pharmaceutical Industry:
1-(4-methoxyphenyl)-2-phenylethanol is used as a chemical intermediate in the synthesis of pharmaceuticals and other organic compounds, contributing to the development of new drugs and medications.
Used in Cosmetics Industry:
In the cosmetics industry, 1-(4-methoxyphenyl)-2-phenylethanol is used as an ingredient to improve the fragrance and overall sensory experience of products such as lotions, creams, and other personal care items.
Used in Antimicrobial Applications:
Due to its antimicrobial properties, 1-(4-methoxyphenyl)-2-phenylethanol can be used in various applications to inhibit the growth of microorganisms, potentially finding use in sanitizing products or as a preservative in the food and cosmetics industries.
Used in Antioxidant Applications:
The antioxidant properties of 1-(4-methoxyphenyl)-2-phenylethanol make it a valuable component in the development of products that require protection against oxidative damage, such as in the food industry to extend shelf life or in the cosmetics industry to protect skin from environmental stressors.

Upstream product

• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 64-17-5 ethanol 
• 123-11-5 4-methoxy-benzaldehyde 
• 6921-34-2 benzylmagnesium chloride 
• 14310-21-5 1-(4-methoxyphenyl)-2-phenylethane 
• 100-39-0 benzyl bromide 
• 128160-29-2 C₁₉H₃₄BrSb 
• 1589-82-8 phenylmagnesium bromide 
• 100-44-7 benzyl chloride 
• 93652-27-8 1-(4-methoxyphenyl)-2-phenylethyl acetate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 122-78-1 phenylacetaldehyde 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 1694-19-5 E-1-(phenyl)-2-(4'-methoxyphenyl)ethene 
• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 123-11-5 4-methoxy-benzaldehyde 
• 140-11-4 Benzyl acetate 
• 113160-01-3 1-[2-methoxy-2-(4-methoxyphenyl)ethyl]benzene 
• 100-52-7 benzaldehyde 
• 100-09-4 4-methoxybenzoic acid 
• 214550-36-4 (+/-)-3-(4'-methoxyphenyl)isochroman 
• 918314-81-5 1-chloro-1-(4-methoxyphenyl)-2-phenylethane 
• 37568-81-3 3,4-dihydro-3-(4-methoxyphenyl)-1H-2-benzopyran-1-one 
• 1016896-38-0 (R)-1-acetoxy-2-phenyl-1-(4-methoxyphenyl)ethane 
• 22711-21-3 4-methoxybenzil 
• 1694-19-5 p-methoxystilbene 
• 121-98-2 methyl 4-methoxybenzoate 

Relevant articles and documents

Intermolecular oxyarylation of olefins with aryl halides and TEMPOH catalyzed by the phenolate anion under visible light

The phenolate anion was discovered as a new photocatalyst with strong reduction potentials. Under visible light irradiation, the phenolate anion enabled the reduction of (hetero)aryl halides (including electron-rich aryl chlorides) to (hetero)aryl radicals through single electron transfer. Based on this new photocatalyst, a novel and efficient photocatalytic protocol for the intermolecular oxyarylation of olefins with aryl halides and TEMPOH was developed. The developed three-component coupling reaction proceeded under redox-neutral reaction conditions with stable and readily available synthons and exhibited broad substrate scope. The utility of this process was further highlighted by the diversified chemical manipulation of the resulting oxyarylation products and the late-stage modification of active pharmaceutical ingredients.

Nitrogen Dioxide Catalyzed Aerobic Oxidative Cleavage of C(OH)–C Bonds of Secondary Alcohols to Produce Acids

Stable organic nitroxyl radicals are an important class of catalysts for oxidation reactions, but their wide applications are hindered by their steric hinderance, high cost, complex operation, and separation procedures. Herein, NO2 in DMSO is shown to effectively catalyze the aerobic oxidative cleavage of C(OH)?C bonds to form a carboxylic group, and NO2 was generated in situ by decomposition of nitrates. A diverse range of secondary alcohols were selectively converted into acids in excellent yields in this transition-metal-free system without any additives. Preliminary results also indicate its applicability to depolymerize recalcitrant macromolecular lignin. Detail studies revealed that NO2 from nitrates promoted the reaction, and NO2 served as hydrogen acceptor and radical initiator for the tandem oxidative reaction.

Chemoselective Benzylation of Aldehydes Using Lewis Base Activated Boronate Nucleophiles

A benzylation of aldehydes using primary and secondary benzylboronic acid pinacol esters is reported. Activation of the boronic ester with s-butyllithium rendered it nucleophilic toward aldehydes. The activated nucleophile chemoselectively transfers the benzyl group over the sec-butyl group, providing excellent yields of the benzylated products. 11B NMR experiments were performed to study the mechanism of this transformation.