5424-47-5Relevant articles and documents
AN IMPROVED PROCESS TO SYNTHESIZE 5-(3-PYRIDYL)-2,2'-BITHIOPHENE(SENSITIZER)
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Page/Page column 9, (2020/12/29)
The present invention discloses an improved catalytic process for the synthesis of 5-(3-pyridyl)-2, 2'-bithiophene in high yield and purity.
Duloxetine hydrochloride salt of basic and duloxetine (by machine translation)
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Paragraph 0053, (2017/06/02)
[Problem] to suppress toxic byproducts, and suppressing the formation of decomposition products of high purity optical isomers as well as the method for manufacturing a basic duloxetine hydrochloride duloxetine. [Solution] a basic manufacturing method of duloxetine, [...], potassium hydroxide and toluene in the presence of alcohol in the mixing step, and, by heating the reaction mixture obtained, comprising the step of distilling off the solvent in the reaction portion, a basic manufacturing method of duloxetine. [Drawing] no (by machine translation)
METHOD FOR PRODUCING DULOXETINE HYDROCHLORIDE
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Paragraph 0062, (2017/05/05)
PROBLEM TO BE SOLVED: To provide a new method for producing (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride (general name: duloxetine hydrochloride) useful as an antidepressant. SOLUTION: In a method for producing duloxetine hydrochloride, a solution obtained by dissolving a crude product containing duloxetine hydrochloride in a dissolving solvent (a first dissolution step) and acetone are mixed (a mixing step), the duloxetine hydrochloride precipitated in the obtained mixed solution is temporarily dissolved (a second dissolution step), and then the duloxetine hydrochloride is precipitated. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT