5428-57-9

Basic information

• Product Name: 2-(biphenyl-4-yl)-1-(morpholin-4-yl)ethanethione
• CAS NO: 5428-57-9
• Molecular Formula: C₁₈H₁₉NOS
• Molecular Weight: 297.4146
• Mol File: 5428-57-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 462.4°C at 760 mmHg
• Flash Point: 233.4°C
• Density: 1.172g/cm³
• Vapor Pressure: 9.93E-09mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: 2-(biphenyl-4-yl)-1-(morpholin-4-yl)ethanethione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(biphenyl-4-yl)-1-(morpholin-4-yl)ethanethione(5428-57-9)
• EPA Substance Registry System: 2-(biphenyl-4-yl)-1-(morpholin-4-yl)ethanethione(5428-57-9)

Safety Data

• Hazardous Substances Data: 5428-57-9(Hazardous Substances Data)

Usage

General Description

2-(biphenyl-4-yl)-1-(morpholin-4-yl)ethanethione is a chemical compound with the molecular formula C18H17NOS. It is a thioamide compound that contains a biphenyl group and a morpholine group. Thioamides are known for their diverse biological activities and have been studied for their potential medicinal properties, including as antimicrobial, antifungal, and antitumor agents. The presence of the morpholine group in this compound suggests potential interactions with biological systems, as morpholine is commonly found in pharmaceuticals and agrochemicals due to its stability and strong solvation properties. The specific properties and potential applications of 2-(biphenyl-4-yl)-1-(morpholin-4-yl)ethanethione would need to be further studied and characterized.

Upstream product

• 110-91-8 morpholine 
• 92-91-1 biphenyl-4-acetaldehyde 
• 2350-89-2 p-vinylbiphenyl 

Downstream Products

• 5728-52-9 (4-biphenylyl)acetic acid 
• 1033590-36-1 1-([1,1'-biphenyl]-4-yl)-2-morpholino-2-thioxoethanone 
• 1393898-15-1 4-(1,1'-biphenyl-4-yl)-5-(morpholin-4-yl)-3-phenylthiophen-2(3H)-one 
• 1417706-38-7 C₂₈H₂₅NO₃S 
• 1417706-41-2 C₂₉H₂₇NO₃S 
• 1430835-46-3 C₂₃H₂₁NO₄S 

Relevant articles and documents

Preparation method of high purity acetyl biphenyl

The invention relates to a preparation method of a high purity biphenyl acetic acid intermediate namely acetyl biphenyl (I). The preparation method is characterized in that 4-dimethylaminopyridine is taken as the catalyst, and biphenyl and acetic anhydride carry out Friedel-Crafts acylation reactions to generate acetyl biphenyl (I). The method has the advantages that 4-dimethylaminopyridine is taken as the catalyst, the obtained product purity is high, the byproducts are few, the purity can reach 99%, the refinement is not needed, and the yield is increased. The impurities are eliminated, so the impurities will not participate in the subsequent reactions and the final product will not contain the impurities. Acetyl biphenyl and morpholine carry out condensation reactions. Finally, the reaction product is saponified and acidified to obtain a crude product. The crude product is refined for once, and the purity can reach 100%. The multiple refinements are eliminated. The product better satisfies the pharmaceutical requirements. The quality of biphenyl acetic acid is improved. The cost is reduced. The total yield is increased from 63-65% to 75-80%.

Solvent-free synthesis of 2-amino-3-aryl-5-substituted thiophenes as anti-inflammatory agents using KF-Al2O3 under microwave irradiation

The synthesis of 2-amino-3-aryl-5-substituted thiophenes as anti-inflammatory agents catalyzed by KF-Al2O3 under microwave irradiation is reported. Copyright Taylor & Francis Group, LLC.

A versatile one-pot synthesis of 2,3,5-tri-substituted thiophenes from thiomorpholides

An efficient method for the preparation of 2,3,5-trisubstituted thiophenes in a one-pot synthesis from thiomorpholides via the thio-Claisen rearrangement was developed.