54314-85-1 Usage
Description
(3-Benzyloxypropyl)triphenylphosphonium Bromide is a complex organic compound with a phosphonium cation and a bromide anion. It is characterized by its unique structure, which includes a benzyloxypropyl group attached to a triphenylphosphonium moiety. (3-BENZYLOXYPROPYL)TRIPHENYLPHOSPHONIUM BROMIDE is known for its potential applications in various chemical and pharmaceutical processes due to its reactivity and stability.
Uses
Used in Pharmaceutical Industry:
(3-Benzyloxypropyl)triphenylphosphonium Bromide is used as a reagent for the preparation of antitumor agents, specifically for the synthesis of geldanamycin and radicicol macrocyclic chimeras. These chimeras exhibit Her2 degradation activity, which is crucial in the development of targeted cancer therapies.
Used in Chemical Synthesis:
(3-Benzyloxypropyl)triphenylphosphonium Bromide is used as a reactant in the preparation of spirocyclohexadienones through Pd-catalyzed intramolecular ipso-Friedel-Crafts allylic alkylation. This reaction is significant in the synthesis of complex organic molecules and pharmaceutical compounds.
Used in Heat Shock Protein Inhibition:
(3-Benzyloxypropyl)triphenylphosphonium Bromide is used as a precursor in the development of inhibitors for heat shock protein (Hsp90), which are potential antitumor agents. Hsp90 is a molecular chaperone that plays a role in the stabilization and activation of various proteins involved in cancer cell survival and proliferation.
Used in Organic Synthesis:
(3-Benzyloxypropyl)triphenylphosphonium Bromide is used as a reactant in the synthesis of carpanone-like molecules through an oxidative coupling/Diels-Alder cycloaddition sequence. This process is essential in the development of novel organic compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 54314-85-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,3,1 and 4 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 54314-85:
(7*5)+(6*4)+(5*3)+(4*1)+(3*4)+(2*8)+(1*5)=111
111 % 10 = 1
So 54314-85-1 is a valid CAS Registry Number.
InChI:InChI=1/C28H28OP.BrH/c1-5-14-25(15-6-1)24-29-22-13-23-30(26-16-7-2-8-17-26,27-18-9-3-10-19-27)28-20-11-4-12-21-28;/h1-12,14-21H,13,22-24H2;1H/q+1;/p-1
54314-85-1Relevant articles and documents
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Hakada,N. et al.
, p. 265 - 270 (1978)
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Acyclic diastereoselection as a synthetic route to quassinoids: A claisen rearrangement based strategy for bruceantin
Ziegler,Klein,Pati,Wang
, p. 2730 - 2737 (2007/10/02)
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11,12-Secoprostaglandins
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, (2008/06/13)
This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of hypertension, for the prevention of thrombus formation, in preventing gastric secretion, and as regulators of the immune response.
