54337-43-8

Basic information

• Product Name: 1-Oxaspiro[2.5]octa-4,7-dien-6-one
• Synonyms: 1-oxa-spiro[2.5]octa-4,7-dien-6-one
• CAS NO: 54337-43-8
• Molecular Formula: C7H6O2
• Molecular Weight: 122.123
• Mol File: 54337-43-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Oxaspiro[2.5]octa-4,7-dien-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Oxaspiro[2.5]octa-4,7-dien-6-one(54337-43-8)
• EPA Substance Registry System: 1-Oxaspiro[2.5]octa-4,7-dien-6-one(54337-43-8)

Safety Data

• Hazardous Substances Data: 54337-43-8(Hazardous Substances Data)

Upstream product

• 623-05-2 (4-hydroxyphenyl)methanol 

Downstream Products

• 50-00-0 formaldehyd 
• 123-31-9 hydroquinone 
• 1041-01-6 3,5-diiodo-L-thyronine 
• 57422-58-9 bis(propylsulfanyl)methane 
• 18979-80-1 4-propylthiophenol 

Relevant articles and documents

A concise synthesis of thyroxine (T4) and 3,5,3'-Triiodo-L-thyronine (T3)

The mono- and di-iodo derivatives of 1-oxaspiro[2,5]bicycloocta-4,7-dien-6-one, 8 and 9, reacted readily with 3,5-diiodo-L-tyrosine at pH 8.0 to give 3,5,3'-triiodo-L-thyronine (T3) and thyroxine in 70% and 94% yields respectively. In turn, 8 and 9 were prepared by the sodium bismuthate oxidation of their corresponding iodinated p-hydroxybenzyl alcohol derivatives, 6 and 7 in 32% and 37% yields.