543729-86-8

Basic information

• Product Name: {5-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-thiazol-2-yl}-carbamic acid tert-butyl ester
• CAS NO: 543729-86-8
• Molecular Weight: 610.847
• Mol File: 543729-86-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {5-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-thiazol-2-yl}-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {5-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-thiazol-2-yl}-carbamic acid tert-butyl ester(543729-86-8)
• EPA Substance Registry System: {5-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-thiazol-2-yl}-carbamic acid tert-butyl ester(543729-86-8)

Safety Data

• Hazardous Substances Data: 543729-86-8(Hazardous Substances Data)

Upstream product

• 170961-15-6 tert-butyl 1,3-thiazole-2-yl-carbamate 
• 130222-84-3 5-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribono-1,4-lactone 

Relevant articles and documents

A short and highly stereoselective synthesis of α-(2-aminothiazolyl)-C-nucleosides

A short route to novel α-(2-aminothiazolyl)-C-nucleosides has been developed. The key step was the high diastereoselective reduction of the hemiacetal intermediates using L-Selectride, which afforded the corresponding R-diols in quantitative yields. These diols were converted, after C4-C1 ring closure and protecting groups cleavage, to their corresponding free α-C-nucleosides.