543729-91-5

Basic information

• Product Name: [5-((R)-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-hydroxy-methyl)-thiazol-2-yl]-carbamic acid tert-butyl ester
• Synonyms: [5-((R)-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-hydroxy-methyl)-thiazol-2-yl]-carbamic acid tert-butyl ester
• CAS NO: 543729-91-5
• Molecular Weight: 628.862
• Mol File: 543729-91-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [5-((R)-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-hydroxy-methyl)-thiazol-2-yl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [5-((R)-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-hydroxy-methyl)-thiazol-2-yl]-carbamic acid tert-butyl ester(543729-91-5)
• EPA Substance Registry System: [5-((R)-{(4S,5R)-5-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-hydroxy-methyl)-thiazol-2-yl]-carbamic acid tert-butyl ester(543729-91-5)

Safety Data

• Hazardous Substances Data: 543729-91-5(Hazardous Substances Data)

Upstream product

• 170961-15-6 tert-butyl 1,3-thiazole-2-yl-carbamate 
• 130222-84-3 5-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribono-1,4-lactone 

Downstream Products

• 71519-70-5 (1S)-1-(2-amino-thiazol-5-yl)-D-1,4-anhydro-ribitol 
• 543729-97-1 {5-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-thiazol-2-yl}-carbamic acid tert-butyl ester 

Relevant articles and documents

A short and highly stereoselective synthesis of α-(2-aminothiazolyl)-C-nucleosides

A short route to novel α-(2-aminothiazolyl)-C-nucleosides has been developed. The key step was the high diastereoselective reduction of the hemiacetal intermediates using L-Selectride, which afforded the corresponding R-diols in quantitative yields. These diols were converted, after C4-C1 ring closure and protecting groups cleavage, to their corresponding free α-C-nucleosides.