54385-06-7

Basic information

• Product Name: 1-[2-(chloroMethyl)-1-pyrrolidinyl]-Ethanone
• Synonyms: 1-[2-(chloroMethyl)-1-pyrrolidinyl]-Ethanone
• CAS NO: 54385-06-7
• Molecular Formula: C7H12ClNO
• Molecular Weight: 161.631
• Mol File: 54385-06-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 68 °C(Press: 0.5 Torr)
• Density: 1.126±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-[2-(chloroMethyl)-1-pyrrolidinyl]-Ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(chloroMethyl)-1-pyrrolidinyl]-Ethanone(54385-06-7)
• EPA Substance Registry System: 1-[2-(chloroMethyl)-1-pyrrolidinyl]-Ethanone(54385-06-7)

Safety Data

• Hazardous Substances Data: 54385-06-7(Hazardous Substances Data)

Usage

Synonym

PCME

Chemical class

Ketones

Molecular weight

167.65 g/mol

Physical state

Colorless liquid

Odor

Slightly sweet

Solubility

Soluble in organic solvents

Uses

a. Research laboratories as a reagent or intermediate
b. Building block in the production of pharmaceuticals and agrochemicals
c. Manufacture of various other chemicals

Hazardous properties

a. Causes irritation to skin, eyes, and respiratory system
b. Harmful if ingested

Safety precautions

Handle and store with care

Upstream product

• 27822-68-0 N-acetylprolinol 
• 498-63-5 2-hydroxymethylpyrrolidine 

Downstream Products

• 133129-46-1 (R)-N-((R)-1-Ethyl-pyrrolidin-2-ylmethyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 133129-46-1 (R)-N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 26116-12-1 1-ethyl-2-pyrrolidinemethanamine 

Relevant articles and documents

Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: High-affinity ligands for CNS dopamine D2 receptors

A number of 2,3-dimethoxy-5-(fluoroalkyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl] benzamides (with or without a 6-hydroxy group) were synthesized and evaluated as dopamine D2 receptor ligands. The parent acids were synthesized via the Claisen rearrangement of the appropriate O-allyl ethers, which were derived from o-vanillic acid or 2,3-dimethoxysalicylic acid. A decrease in reactivity was found to be characteristic of pentasubstituted benzoates, and difficulties were encountered with the introduction of fluorine onto the ethyl side chains. The (fluoroethyl)- and (fluoropropyl)salicylamides were 5 times more potent than the corresponding benzamides in inhibiting [3H]spiperone binding to the D2 receptor. These (fluoroalkyl)salicylamides are of potential value for in vivo positron emission tomography (PET) studies upon the basis of their relatively selective, high potency binding affinity for the D2 receptor.