54397-10-3

Basic information

• Product Name: 2-(4-chlorophenyl)-3-phenylthiazolidin-4-one
• Synonyms: 2-(4-chlorophenyl)-3-phenylthiazolidin-4-one
• CAS NO: 54397-10-3
• Molecular Formula: C₁₅H₁₂ClNOS
• Molecular Weight: 289.77988
• Mol File: 54397-10-3.mol
• Article Data: 32

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-chlorophenyl)-3-phenylthiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-3-phenylthiazolidin-4-one(54397-10-3)
• EPA Substance Registry System: 2-(4-chlorophenyl)-3-phenylthiazolidin-4-one(54397-10-3)

Safety Data

• Hazardous Substances Data: 54397-10-3(Hazardous Substances Data)

Upstream product

• 30298-36-3 2-mercaptothioacetic acid 
• 2362-79-0 N-(4-chlorobenzylidene)aniline 
• 104-88-1 4-chlorobenzaldehyde 
• 68-11-1 mercaptoacetic acid 
• 62-53-3 aniline 
• 1613-95-2 (E)-1-(4-chlorophenyl)-N-phenylmethanimine 
• 622-37-7 Phenyl azide 
• 623-51-8 ethyl 2-sulfanylacetate 

Downstream Products

• 54397-12-5 2-(4-chloro-phenyl)-5-(4-dimethylamino-benzylidene)-3-phenyl-thiazolidin-4-one 
• 78830-95-2 2-(4-chlorophenyl)-3-phenyl-4-oxothiazolidine 1-oxide 
• 130887-93-3 2-(4-chlorophenyl)-3-phenyl-5-phenylmethylene-4-oxo-1,3-thiazolidine 
• 130887-96-6 2-(4-chlorophenyl)-3-phenyl-5-phenylmethylene-4-oxo-1,3-thiazolidine-1-oxide 
• 130888-01-6 2-(4-chlorophenyl)-3-phenyl-5-diphenylmethyl-4-oxo-1,3-thiazolidine-1-oxide 

Relevant articles and documents

Preparation of thiazolidin-4-one derivatives using ZnO–NiO–NiFe2O4 nano-composite system

The hydrothermal synthesis of ZnO–NiO–NiFe2O4 nano-composite is reported. The sample was utilized to characterize via XRD, FE-SEM, EDS, FT-IR, UV–Vis, and BET techniques. The sample consisted of three different phases as ZnO (hexagonal), NiO (cubic), and NiFe2O4 (cubic) with the average particle size as 34?nm and specific surface area, average pore diameter, and pore volume as 64.35?m2?g?1, 13.02?nm, and 0.201?cm3?g?1, respectively. Catalytic behavior of the nano-composite was investigated on the synthesis of thiazolidin-4-one derivatives under thermal and ultrasonic irradiation condition. Our results show that the catalytic activity of ZnO–NiO–NiFe2O4 nano-composite is much higher than ZnO, NiO, and NiFe2O4 metal oxides. All products were prepared in high yields with short reaction times. In addition, the catalyst was recovered for at least five times.

Silica chloride (SiO2-Cl) catalyzed one pot synthesis of 2,3-disubstituted-thiazolidin-4-one

In this paper, we report one-pot, three-component cyclo condensation of an aldehyde, an amine and thioglycolic acid to form 2,3-disubstituted-thiazolidin-4-one by using supported protic acid (Silica Chloride: SiO2-Cl) catalyst. The catalyst SiO2-Cl is compatible with a variety of aldehydes (aryl/heteroaryl) and the aromatic amines affording 2,3-disubstituted-thiazolidin-4-one analogs in 72–89% yields. Moreover, the supported catalyst was recycled several times without significant loss of catalytical activity.

TS-1 zeolite as a Lewis acid catalyst for solvent-free one-pot synthesis of 1,3-thiazolidin-4-ones

Abstract: Titanium silicate (TS-1) zeolite heterogeneous catalyst is synthesized by the hydrothermally discontinuous method and is characterized by using XRD, SEM, TEM, and NH3–TPD techniques. The catalytic activity of the TS-1 type zeolite was tested for one-pot solvent-free synthesis of 1,3-thiazolidine-4-ones. The present technique illustrates many benefits, including eco-friendly reaction conditions, environmentally helpful, short response time, simplicity, straightforward separatation, catalyst reusability and high yields of the products. Furthermore, the catalyst was utilized for four recycle reactions and it has been found that the catalyst shows consistent chemical process activity. Graphical abstract: [Figure not available: see fulltext.].