5440-44-8

Basic information

• Product Name: 2-acetamido-5-phenyl-pentanoic acid
• Synonyms: 2-acetamido-5-phenyl-pentanoic acid
• CAS NO: 5440-44-8
• Molecular Formula: C13H17NO3
• Molecular Weight: 235.279
• Mol File: 5440-44-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 506.4°Cat760mmHg
• Flash Point: 260.1°C
• Appearance: /
• Density: 1.143g/cm³
• Vapor Pressure: 4.45E-11mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: 2-acetamido-5-phenyl-pentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetamido-5-phenyl-pentanoic acid(5440-44-8)
• EPA Substance Registry System: 2-acetamido-5-phenyl-pentanoic acid(5440-44-8)

Safety Data

• Hazardous Substances Data: 5440-44-8(Hazardous Substances Data)

Usage

Classification

Nonsteroidal anti-inflammatory drug (NSAID)

Common uses

Treating pain and inflammation, often prescribed for rheumatoid arthritis, osteoarthritis, and menstrual pain

Mechanism of action

Inhibits the production of prostaglandins, which are chemicals in the body that cause pain and swelling

Available forms

Oral tablets and capsules

Administration

Typically taken with food to prevent stomach upset

Side effects

Stomach ulcers, gastrointestinal bleeding, and increased risk of heart attack or stroke (particularly with long-term use or in higher doses)

Precautions

Use the medication only as directed by a healthcare professional and closely monitor for any adverse effects

InChI:InChI=1/C13H17NO3/c1-10(15)14-12(13(16)17)9-5-8-11-6-3-2-4-7-11/h2-4,6-7,12H,5,8-9H2,1H3,(H,14,15)(H,16,17)

Upstream product

• 108246-15-7 (+/-)-4-Acetamino-1-phenyl-penten-⁽¹⁾-saeure-⁽⁵⁾ 
• 52161-73-6 2-acetylamino-2-(3-phenyl-propyl)malonic acid diethyl ester 
• 637-59-2 1-Bromo-3-phenylpropane 
• 101782-54-1 Acetamino-cinnamyl-malonsaeure-diethylester 
• 4392-24-9 Cinnamyl bromide 
• 62732-55-2 2-Acetylamino-2-(3-phenyl-propyl)-malonic acid 
• 108019-30-3 DL-N-acetyl-2-amino-5-phenylpentanoic acid 

Downstream Products

• 106270-07-9 2-methyl-4-(3-phenyl-propyl)-4H-oxazol-5-one 

Relevant articles and documents

Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues

A series of growth hormone secretagogues (GHSs) based on 2,3-dihydroisothiazole has been synthesized in the search for a potential treatment of growth hormone deficiency or frailty in the elderly. This paper describes the evaluation of the SAR of the benzyl-d-Ser-aminoisobutyric acid dipeptide fragment. Introduction of substituents in the peptide backbone and in the phenyl ring has been investigated, as well as replacements for the benzyl group and for the AIB residue. A number of modifications resulted in enhanced potency over the parent benzyl-d-Ser-AIB derivative.

STEREOSELECTIVE PROCESS FOR THE SYNTHESIS OF (D)-2-AMINO-5-PHENYLPENTANOIC OR ALKYL ESTER THEREOF

The present invention provides a process for preparing a compound of formula (I); wherein R is a C1-C6 alkyl; or a salt thereof; comprising:(c) hydrolyzing (D,L)-N-acetyl-2-amino-5-phenylpentanoic acid with a suitable base in the pre

Substituted acetamidomalonic esters and DL-2-acetamido acids as antitumor agents.

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