54431-30-0

Basic information

• Product Name: L-Proline, 1-(4,5-dimethoxy-2-nitrobenzoyl)-4-hydroxy-, methyl ester, (4R)-
• CAS NO: 54431-30-0
• Molecular Formula: C15H18N2O8
• Molecular Weight: 354.317
• Mol File: 54431-30-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Proline, 1-(4,5-dimethoxy-2-nitrobenzoyl)-4-hydroxy-, methyl ester, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 1-(4,5-dimethoxy-2-nitrobenzoyl)-4-hydroxy-, methyl ester, (4R)-(54431-30-0)
• EPA Substance Registry System: L-Proline, 1-(4,5-dimethoxy-2-nitrobenzoyl)-4-hydroxy-, methyl ester, (4R)-(54431-30-0)

Safety Data

• Hazardous Substances Data: 54431-30-0(Hazardous Substances Data)

Upstream product

• 29568-78-3 4,5-dimethoxy-2-nitrobenzoyl chloride 
• 4998-07-6 4,5-dimethoxy-2-nitro-benzoic acid 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 

Downstream Products

• 1006904-27-3 C₁₆H₂₀N₂O₁₀S 
• 489475-05-0 (11aS)-1,11a-dihydro-10-(2-trimethylsilanylethoxymethyl)-7,8-dimethoxy-2-p-tolyl-5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione 
• 260418-09-5 (11aS)-7,8-dimethoxy-2-(4-methoxyphenyl)-5,10,11,11a-tetrahydro-10-[2-(trimethylsilyl)ethoxymethyl]-5,11-dioxo-1H-pyrrolo[2,1-c][1,4-]benzodiazepine 
• 260418-10-8 (11aS)-7,8-dimethoxy-2-phenyl-5,10,11,11a-tetrahydro-10-[2-(trimethylsilyl)ethoxymethyl]-5,11-dioxo-1H-pyrrolo[2,1-c][1,4-]benzodiazepine 
• 757189-89-2 (2S,4R)-N-[4,5-dimethoxy-2-nitrobenzoyl]-4-(t-butyldimethylsilyl)-oxypyrrolidine-2-carboxaldehyde 
• 757189-90-5 (2S,4R)-N-[4,5-dimethoxy-2-nitrobenzoyl]-4-hydroxypyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 757189-88-1 methyl (2S,4R)-N-[4,5-dimethoxy-2-nitrobenzoyl]-4-(t-butyldimethylsilyl)-oxypyrrolidine-2-carboxylate 

Relevant articles and documents

Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1- c ][1,4]benzodiazepine (PBD) antitumor agents

A comprehensive SAR investigation of the C2-position of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) monomer antitumor agents is reported, establishing the molecular requirements for optimal in vitro cytotoxicity and DNA-binding affinity. Both carbocyclic and

PYRROLOBENZODIAZEPINES

Compounds of formula (I) : formula (I) and salts, solvates, chemically protected forms, and prodrugs thereof, are disclosed wherein R2 is selected from: an optionally substituted napthyl group; an optionally substituted thiophenyl or furanyl gr

Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents

Three novel C2-aryl substituted pyrrolobenzodiazepines (PBDs) have been synthesised and evaluated in a number of cell lines revealing selective cytotoxicity at the sub-nanomolar level towards melanoma and ovarian cancer cell lines.