5444-91-7

Basic information

• Product Name: 1H-Indole,3-[(4-methyl-1-piperazinyl)methyl]-
• Synonyms: 1H-Indole,3-[(4-methyl-1-piperazinyl)methyl]-;3-((4-METHYLPIPERAZIN-1-YL)METHYL)-1H-INDOLE;3-[(4-methyl-1-piperazinyl)methyl]-1H-indole
• CAS NO: 5444-91-7
• Molecular Formula: C₁₄H₁₉N₃
• Molecular Weight: 229.32076
• Mol File: 5444-91-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 386.3°C at 760 mmHg
• Flash Point: 187.4°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 3.59E-06mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: 1H-Indole,3-[(4-methyl-1-piperazinyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole,3-[(4-methyl-1-piperazinyl)methyl]-(5444-91-7)
• EPA Substance Registry System: 1H-Indole,3-[(4-methyl-1-piperazinyl)methyl]-(5444-91-7)

Safety Data

• Hazardous Substances Data: 5444-91-7(Hazardous Substances Data)

Usage

Explanation

This is the chemical name of the compound, also known as mirtazapine.

Explanation

Mirtazapine is a psychoactive substance that affects the central nervous system and has an impact on mood and emotions.

Explanation

Mirtazapine is primarily used to treat major depressive disorder by alleviating depressive symptoms.

Explanation

The molecular structure of mirtazapine consists of an indole ring system with a specific side chain attached, which contributes to its pharmacological properties.

Explanation

Mirtazapine acts as an antagonist at certain serotonin and adrenergic receptors in the brain, which helps regulate mood and emotions.

Explanation

Mirtazapine increases the levels of certain neurotransmitters, such as norepinephrine and serotonin, which play a role in mood regulation and emotional well-being.

Explanation

Apart from treating major depressive disorder, mirtazapine has also been found effective in managing anxiety, insomnia, and other mood-related disorders.

Treatment

Major depressive disorder

Chemical structure

Indole ring with a 4-methylpiperazinylmethyl side chain at the 3-position

Mechanism of action

Noradrenergic and specific serotonergic antidepressant (NaSSA)

Additional therapeutic uses

Anxiety, insomnia, and other mood disorders

InChI:InChI=1/C14H19N3/c1-16-6-8-17(9-7-16)11-12-10-15-14-5-3-2-4-13(12)14/h2-5,10,15H,6-9,11H2,1H3

Upstream product

• 120-72-9 indole 
• 19212-84-1 1-[(4-methylpiperazin-1-yl)methyl]-1H-1,2,3-benzotriazole 
• 109-01-3 1-methyl-piperazine 
• 50-00-0 formaldehyd 
• 29919-22-0 1-(indole-3-carbonyl)-4-methyl-piperazine 
• 87-52-5 3-(Dimethylaminomethyl)indole 
• 771-50-6 1H-indole-3-carboxylic acid 

Relevant articles and documents

Synthesis and characterization of 3-substituted indole derivatives as novel mannich bases

In this study, ten 3-substituted indole derivatives at the 3rdposition of indole nucleus were synthesized via Mannich reaction with microwave assisted synthesis and the conventional reflux heating method. Microwave assisted synthesis is more pr

Bioactivity-guided synthesis of gramine derivatives as new MT1 and 5-HT1A receptors agonists

Twenty-four gramine derivatives were synthesized and evaluated on MT1 and 5-HT1A receptors in vitro. Among them, seven derivatives (7, 8, 16, 19, 20, 21, and 24) exhibited higher agonisting activities on MT1 or 5-HT1A

N-ARYLSULFONYL-3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

The present invention relates to novel N-arylsulfonyl-3-substituted indole compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their geometric forms, their N-oxides, their polymorphs, their pharmaceutically acceptable