544417-30-3

Basic information

• Product Name: (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide
• Synonyms: (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide
• CAS NO: 544417-30-3
• Molecular Weight: 556.064
• Mol File: 544417-30-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide(544417-30-3)
• EPA Substance Registry System: (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide(544417-30-3)

Safety Data

• Hazardous Substances Data: 544417-30-3(Hazardous Substances Data)

Upstream product

• 1055943-40-2 trans-4-dimethylamino crotonic acid chloride hydrochloride salt 
• 544417-29-0 6-amino-4-(4-benzyloxy-3-chlorophenylamino)-7-ethoxyquinoline-3-carbonitrile 
• 214476-09-2 4-Chloro-7-ethoxy-6-nitro-quinoline-3-carbonitrile 
• 144347-32-0 4-benzyloxy-3-chloroaniline 
• 1056149-69-9 (2E)-(N,N-dimethylamino)-2-butenoyl chloride 
• 1130155-48-4 (E)-4-(dimethylamino)-2-butenoic acid hydrochloride 

Downstream Products

• 915942-27-7 (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-buteneamide maleate 
• 544417-27-8 N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-3,4-bis(dimethylamino)butanamide 

Relevant articles and documents

Methods of synthesizing substituted 3-cyanoquinolines and intermediates thereof

The invention is directed to methods of making substituted 3-cyanoquinolines, including compounds according to the following formula: The methods are amenable to large scale manufacture, avoid the use of chromatographic separations, and provide stable, high purity product more efficiently than in the prior art.

SUBSTITUTED QUINOLINES AS PROTEIN TYROSINE KINASE ENZYME INHIBITORS

This invention provides compounds of formula (I), having the structure wherein R1, R2, R3 are described within the specification. The compounds act as anti-cancer agents by inhibition of HER-2 and EGFR.