544467-02-9

Basic information

• Product Name: 1-(3,5-bis-azidomethyl-phenyl)-ethanone
• CAS NO: 544467-02-9
• Molecular Weight: 230.229
• Mol File: 544467-02-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3,5-bis-azidomethyl-phenyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,5-bis-azidomethyl-phenyl)-ethanone(544467-02-9)
• EPA Substance Registry System: 1-(3,5-bis-azidomethyl-phenyl)-ethanone(544467-02-9)

Safety Data

• Hazardous Substances Data: 544467-02-9(Hazardous Substances Data)

Upstream product

• 5379-16-8 3,5-dimethylacetophenone 
• 544467-01-8 1-(3,5-bis-bromomethyl-phenyl)-ethanone 

Relevant articles and documents

Azido-containing aryl β-diketo acid HIV-1 integrase inhibitors

Aryl β-diketo acids (ADK) comprise a general class of potent HIV-1 integrase (IN) inhibitors, which can exhibit selective inhibition of strand transfer reactions in extracellular recombinant IN assays and provide potent antiviral effects in HIV-infected cells. Recent studies have shown that polycyclic aryl or aryl rings bearing aryl-containing substituents are components of potent members of this class. Reported herein is the first use of azido functionality as an aryl replacement in β-diketo acid IN inhibitors. The ability of azido-containing inhibitors to exhibit potent inhibition of IN and antiviral protection in HIV-infected cells, renders the azide group of potential value in the further development of ADK-based IN inhibitors.