544478-05-9

Basic information

• Product Name: 4-benzyl-N-tritylpiperidine
• Synonyms: 4-benzyl-N-tritylpiperidine
• CAS NO: 544478-05-9
• Molecular Weight: 417.594
• Mol File: 544478-05-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-benzyl-N-tritylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-N-tritylpiperidine(544478-05-9)
• EPA Substance Registry System: 4-benzyl-N-tritylpiperidine(544478-05-9)

Safety Data

• Hazardous Substances Data: 544478-05-9(Hazardous Substances Data)

Upstream product

• 31252-42-3 4-benzylpyperidine 
• 76-83-5 trityl chloride 

Downstream Products

• 31252-42-3 4-benzylpyperidine 
• 251107-37-6 1-t-butyloxycarbonyl-4-benzylpiperidine 

Relevant articles and documents

Detritylation of N-tritylamines via a naphthalene-catalyzed lithiation process

The reaction of aliphatic and aromatic secondary and tertiary N-tritylamines 1 with lithium powder and a catalytic amount of naphthalene led to reductive detritylation, affording the corresponding amines 2 in good to excellent yields. The trityl group could selectively be removed in the presence of an allyl or a benzyl group. The detritylation process could successfully be extended to several hydroxy, alkoxy and amino functionalized N-tritylamines. The chemoselectivity between the trityl-nitrogen and the trityl-oxygen bond cleavages was also studied. This methodology represents an efficient deprotection of N-tritylamines under nonacidic reaction conditions.