5446-25-3

Basic information

• Product Name: 3-chloro-N-(3,4-dimethylphenyl)propanamide
• Synonyms: UKRORGSYN-BB BBV-024046;3-chloro-N-(3,4-dimethylphenyl)propanamide(SALTDATA: FREE);3-chloro-N-(3,4-dimethylphenyl)propionamide;3-chloro-N-(3,4-dimethylphenyl)propanamide
• CAS NO: 5446-25-3
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.69
• Mol File: 5446-25-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 369.4°C at 760 mmHg
• Flash Point: 177.2°C
• Appearance: /
• Density: 1.157g/cm³
• Vapor Pressure: 1.19E-05mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 3-chloro-N-(3,4-dimethylphenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-N-(3,4-dimethylphenyl)propanamide(5446-25-3)
• EPA Substance Registry System: 3-chloro-N-(3,4-dimethylphenyl)propanamide(5446-25-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5446-25-3(Hazardous Substances Data)

Usage

General Description

3-chloro-N-(3,4-dimethylphenyl)propanamide is a chemical compound with the molecular formula C11H14ClNO. It is a derivative of propanamide, with a chlorine atom and a 3,4-dimethylphenyl group attached to the nitrogen atom. 3-chloro-N-(3,4-dimethylphenyl)propanamide is commonly used as an intermediate in the synthesis of other organic compounds, especially pharmaceuticals and agrochemicals. It is also utilized in the production of various polymers and plastics. 3-chloro-N-(3,4-dimethylphenyl)propanamide is a white solid with a high melting point, and its properties and reactivity are important in a wide range of industrial and research applications.

InChI:InChI=1/C11H14ClNO/c1-8-3-4-10(7-9(8)2)13-11(14)5-6-12/h3-4,7H,5-6H2,1-2H3,(H,13,14)

Upstream product

• 95-64-7 4-amino-o-xylene 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 182052-67-1 2-Chloro-3-chloromethyl-6,7-dimethyl-quinoline 
• 60284-48-2 1-(3,4-dimethyl-phenyl)-azetidin-2-one 
• 1012918-33-0 3-(diethylamino)-N-(3,4-dimethyl-phenyl)propionamide 

Relevant articles and documents

Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction

Recent target validation studies have shown that inhibition of the protein interaction between annexin A2 and the S100A10 protein may have potential therapeutic benefits in cancer. Virtual screening identified certain 3,4,5-trisubstituted 4H-1,2,4-triazoles as moderately potent inhibitors of this interaction. A series of analogues were synthesized based on the 1,2,4-triazole scaffold and were evaluated for inhibition of the annexin A2-S100A10 protein interaction in competitive binding assays. 2-[(5-{[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]methyl}-4-(furan-2-ylmethyl)-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[4-(propan-2-yl)phenyl]acetamide (36) showed improved potency and was shown to disrupt the native complex between annexin A2 and S100A10.

New heteroaryl-spaced phosphono α-amino acids are competitive NMDA antagonists with analgesic activity

The synthesis and the NMDA receptor binding affinities of α-amino-3-(phosphonomethyl)-2-naphthalenepropanoic acid, α-amino-3-(phosphonomethyl)-2-benzofuranpropanoic acid, a series of substituted (R)-α-amino-3-(phosphonomethyl)-2-quinolinepropanoic acids, (R)-α-amino-3-(phosphonomethyl)-1,8-naphthyridine-2-propanoic acid and (R)-α-amino-3-(phosphonomethyl)-1,6-naphthyridine-2-propanoic acid are reported.