5446-57-1

Basic information

• Product Name: 2-cyano-2-(4-methoxyphenyl)acetamide
• Synonyms: 2-cyano-2-(4-methoxyphenyl)acetamide
• CAS NO: 5446-57-1
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.2
• Mol File: 5446-57-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 392.5°Cat760mmHg
• Flash Point: 191.2°C
• Appearance: /
• Density: 1.206g/cm³
• Vapor Pressure: 2.28E-06mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 2-cyano-2-(4-methoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyano-2-(4-methoxyphenyl)acetamide(5446-57-1)
• EPA Substance Registry System: 2-cyano-2-(4-methoxyphenyl)acetamide(5446-57-1)

Safety Data

• Hazardous Substances Data: 5446-57-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10N2O2/c1-14-8-4-2-7(3-5-8)9(6-11)10(12)13/h2-5,9H,1H3,(H2,12,13)

Upstream product

• 147795-54-8 ethyl 2-cyano-2-(4-methoxyphenyl)acetate 
• 104-47-2 p-methoxybenzylnitrile 
• 30698-32-9 methyl 2-cyano-2-(4-methoxyphenyl) acetate 

Downstream Products

• 1015699-25-8 C₂₀H₂₁N₃O₂ 
• 1015699-30-5 C₂₀H₂₀N₂O₂S 
• 1015699-21-4 C₂₄H₂₆N₂O₄ 
• 1015699-27-0 C₂₃H₂₄N₂O₄ 
• 1015699-24-7 C₂₄H₂₃N₃O₂ 
• 33534-87-1 α-(p-Methoxyphenyl)-malononitrile 

Relevant articles and documents

Preparation of O-Protected Cyanohydrins by Aerobic Oxidation of α-Substituted Malononitriles in the Presence of Diarylphosphine Oxides

A mild, reagent-cyanide-free, and efficient synthesis of O-phosphinoyl-protected cyanohydrins from readily available α-substituted malononitriles was realized using diarylphosphine oxides in the presence of O2. Mechanistic studies indicated that in addition to the initial aerobic oxidation of the malononitrile derivative notable features of this process include the formation of a tetrahedral intermediate and a subsequent intramolecular rearrangement. The phosphinoyl-protecting group can be removed by alcoholysis or by reduction with DIBAL-H.