5447-28-9Relevant articles and documents
Direct intermolecular aniline ortho- arylation via benzyne intermediates
Truong, Thanh,Daugulis, Olafs
supporting information, p. 5964 - 5967 (2013/02/22)
A method for direct, transition-metal-free ortho-arylation of anilines by aryl chlorides, bromides, fluorides, and triflates has been developed. This methodology provides the most direct approach to 2-arylanilines since no protecting or directing groups on nitrogen are required. The arylation is functional-group tolerant, with alkene, ether, trifluoromethyl, dimethylamino, carbonyl, chloro, and cyano functionalities tolerated. Phenylation of enantiopure binaphthyldiamine affords a product with >99% ee.