5449-50-3

Basic information

• Product Name: biphenyl-4-yl(phenyl)acetic acid
• CAS NO: 5449-50-3
• Molecular Formula: C₂₀H₁₆O₂
• Molecular Weight: 288.3398
• Mol File: 5449-50-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 410°C at 760 mmHg
• Flash Point: 215.9°C
• Density: 1.172g/cm³
• Vapor Pressure: 1.86E-07mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: biphenyl-4-yl(phenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: biphenyl-4-yl(phenyl)acetic acid(5449-50-3)
• EPA Substance Registry System: biphenyl-4-yl(phenyl)acetic acid(5449-50-3)

Safety Data

• Hazardous Substances Data: 5449-50-3(Hazardous Substances Data)

Upstream product

• 5449-51-4 2-([1,1'-biphenyl]-4-yl)-2-hydroxy-2-phenylacetic acid 
• 92-52-4 biphenyl 
• 6244-53-7 ethyl (4-phenylphenyl)glyoxylate 
• 124-38-9 carbon dioxide 
• 613-42-3 4-benzylbiphenyl 

Downstream Products

• 21175-18-8 (E)-4-phenylstilbene 
• 1070673-92-5 2-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-phenylacetamide 

Relevant articles and documents

Visible-Light-Driven External-Reductant-Free Cross-Electrophile Couplings of Tetraalkyl Ammonium Salts

Cross-electrophile couplings between two electrophiles are powerful and economic methods to generate C-C bonds in the presence of stoichiometric external reductants. Herein, we report a novel strategy to realize the first external-reductant-free cross-electrophile coupling via visible-light photoredox catalysis. A variety of tetraalkyl ammonium salts, bearing primary, secondary, and tertiary C-N bonds, undergo selective couplings with aldehydes/ketone and CO2. Notably, the in situ generated byproduct, trimethylamine, is efficiently utilized as the electron donor. Moreover, this protocol exhibits mild reaction conditions, low catalyst loading, broad substrate scope, good functional group tolerance, and facile scalability. Mechanistic studies indicate that benzyl radicals and anions might be generated as the key intermediates via photocatalysis, providing a new direction for cross-electrophile couplings.

INHIBITORS OF HISTONE DEACETYLASE

This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.