5452-46-0

Basic information

• Product Name: 4-(3,4-DIMETHOXYPHENYL)-1-BUTEN-4-OL
• Synonyms: 4-(3,4-DIMETHOXYPHENYL)-1-BUTEN-4-OL
• CAS NO: 5452-46-0
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.25
• Mol File: 5452-46-0.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 322.5°C at 760 mmHg
• Flash Point: 148.9°C
• Appearance: /
• Density: 1.059g/cm³
• Vapor Pressure: 0.000114mmHg at 25°C
• Refractive Index: 1.519
• CAS DataBase Reference: 4-(3,4-DIMETHOXYPHENYL)-1-BUTEN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,4-DIMETHOXYPHENYL)-1-BUTEN-4-OL(5452-46-0)
• EPA Substance Registry System: 4-(3,4-DIMETHOXYPHENYL)-1-BUTEN-4-OL(5452-46-0)

Safety Data

• Hazardous Substances Data: 5452-46-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H16O3/c1-4-5-10(13)9-6-7-11(14-2)12(8-9)15-3/h4,6-8,10,13H,1,5H2,2-3H3

Upstream product

• 2622-05-1 allylmagnesium bromide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 1730-25-2 allylmagnesium bromide 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 
• 80696-81-7 4-bromo-5-(1-hydroxybut-3-en-1-yl)veratrole 
• 107-05-1 3-chloroprop-1-ene 
• 106-95-6 allyl bromide 
• 24850-33-7 allyltributylstanane 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 72824-04-5 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 591-87-7 Allyl acetate 

Downstream Products

• 57746-45-9 (+/-)-3c-(3.4-dimethoxy-phenyl)-cyclohexene-⁽⁴⁾-dicarboxylic acid-(1r.2c) 
• 115881-08-8 N-<1-(3,4-dimethoxyphenyl)but-3-en-1-yl>glutarimide 
• 880262-17-9 1-(3,4-dimethoxyphenyl)-2-oxiranylethanol 
• 880262-22-6 2-[2-(3,4-dimethoxyphenyl)-2-(prop-2-ynyloxy)ethyl]oxirane 
• 88931-04-8 (2RS,4RS,9aSR)-4-(3,4-dimethoxyphenyl)octahydro-2H-quinolizin-2-ol 
• 115881-10-2 5-Oxo-pentanoic acid [1-(3,4-dimethoxy-phenyl)-but-3-enyl]-amide 
• 115881-09-9 1-[1-(3,4-Dimethoxy-phenyl)-but-3-enyl]-6-hydroxy-piperidin-2-one 
• 28268-66-8 (+/-)-3c-(3.4-dimethoxy-phenyl)-cyclohexene-⁽⁴⁾-dicarboxylic acid-(1r.2c)-dimethyl ester 
• 1094999-08-2 C₁₅H₁₉BrO₃ 
• 1315491-59-8 (S)-4-benzyl-3-[(1R,2S)-2-(3,4-dimethoxyphenyl)cyclohex-3-ene-1-carbonyl]oxazolidin-2-one 
• 1315491-63-4 (1R,2S)-[2-(3,4-dimethoxyphenyl)cyclohex-3-enyl]methanol 
• 1315491-57-6 (1R,2S)-2-(3,4-dimethoxyphenyl)cyclohex-3-enecarbaldehyde 

Relevant articles and documents

Efficient solvent-free in situ tin-mediated homoallylation reactions

Various carbonyl compounds were converted to their corresponding homoallylic alcohols under ultrasonic irradiation and solvent free conditions, in the presence of metallic Sn and excess allyl bromide. Diallyltin(IV) dibromide was identified as the reactiv

Ni-Catalyzed 1,2-Diarylation of Alkenyl Ketones: A Comparative Study of Carbonyl-Directed Reaction Systems

A nickel-catalyzed 1,2-diarylation of alkenyl ketones with aryl iodides and arylboronic esters is reported. Ketones with a variety of substituents serve as effective directing groups, offering high levels of regiocontrol. A representative product is diversified into a wide range of useful products that are not readily accessible via existing 1,2-diarylation reactions. Preliminary mechanistic studies shed light on the binding mode of the substrate, and Hammett analysis reveals the effect of electronic factors on initial rates.

MnO2as a terminal oxidant in Wacker oxidation of homoallyl alcohols and terminal olefins

Efficient and mild reaction conditions for Wacker-type oxidation of terminal olefins of less explored homoallyl alcohols to β-hydroxy-methyl ketones have been developed by using a Pd(ii) catalyst and MnO2 as a co-oxidant. The method involves mild reaction conditions and shows good functional group compatibility along with high regio- and chemoselectivity. While our earlier system of PdCl2/CrO3/HCl produced α,β-unsaturated ketones from homoallyl alcohols, the present method provided orthogonally the β-hydroxy-methyl ketones. No overoxidation or elimination of benzylic and/or β-hydroxy groups was observed. The method could be extended to the oxidation of simple terminal olefins as well, to methyl ketones, displaying its versatility. An application to the regioselective synthesis of gingerol is demonstrated.