5453-48-5

Basic information

• Product Name: N-(4-CHLOROPHENYL) ACRYLAMIDE
• Synonyms: N-(4-CHLOROPHENYL) ACRYLAMIDE;N-(4-chlorophenyl)prop-2-enamide
• CAS NO: 5453-48-5
• Molecular Formula: C₉H₈ClNO
• Molecular Weight: 181.62
• Product Categories: monomer
• Mol File: 5453-48-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 338.7°Cat760mmHg
• Flash Point: 158.7°C
• Appearance: /
• Density: 1.243g/cm³
• Vapor Pressure: 9.63E-05mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-(4-CHLOROPHENYL) ACRYLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-CHLOROPHENYL) ACRYLAMIDE(5453-48-5)
• EPA Substance Registry System: N-(4-CHLOROPHENYL) ACRYLAMIDE(5453-48-5)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 5453-48-5(Hazardous Substances Data)

Usage

General Description

N-(4-Chlorophenyl) acrylamide, also known as N-(p-Chlorophenyl) acrylamide, is a chemical compound with the molecular formula C9H8ClNO. This molecule contains the functional groups of acrylamides, chlorophenyls, and anilines and commonly used in academic and industrial sectors as a reagent in chemical synthesis and other chemical processes. Notably, N-(4-Chlorophenyl) acrylamide is characterized by a chlorine atom attached to a phenyl ring, which can react under certain conditions to provide diverse molecules for potential use in different chemical fields. However, due to the reactivity and potential toxicity of compounds in this class, careful handling and appropriate safety measures are required when working with this material.

InChI:InChI=1/C9H8ClNO/c1-2-9(12)11-8-5-3-7(10)4-6-8/h2-6H,1H2,(H,11,12)

Upstream product

• 126545-19-5 N-methoxy-N-phenylacrylamide 
• 340011-45-2 N-(4-chlorophenyl)-3-(phenylsulfonyl)propanamide 
• 590-92-1 3-Bromopropionic acid 
• 106-47-8 4-chloro-aniline 
• 598-72-1 2-Bromopropionic acid 
• 100-00-5 4-chlorobenzonitrile 
• 140-88-5 ethyl acrylate 
• 637-87-6 1-Chloro-4-iodobenzene 
• 79-06-1 2-propenamide 
• 16619-64-0 1-(2-chlorophenyl)-3-phenyl-2-propyn-1-one 
• 814-68-6 acryloyl chloride 

Downstream Products

• 86524-03-0 N-(4-Chloro-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide 
• 108811-82-1 1,4,5,6,7,7-Hexabromo-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (4-chloro-phenyl)-amide 
• 340011-50-9 N-allyl N-(4-chlorophenyl)acrylamide 
• 434288-45-6 N-(4-chlorophenyl)-3-cyclohexylpropanamide 

Relevant articles and documents

COMPOSITONS AND METHODS FOR MODULATING UBA5

Disclosed herein, inter alia, are compositions and methods useful for inhibiting ubiquitin-like modifier activating enzyme 5.

COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4

Disclosed herein, inter alia, are compositions and methods useful for inhibiting reticulon 4(RTN4).

Ligand-free CuTC-catalyzed N-arylation of amides, anilines and 4-aminoantipyrine: Synthesis of N-arylacrylamides, 4-amido-N-phenylbenzamides and 4-amino(N-phenyl)antipyrenes

N-Arylation of amides and anilines with aryl iodides was efficiently catalyzed by copper thiophenecarboxylate under ligand-free conditions with good to excellent yields. A variety of substituted aryl iodides, amides, anilines and 4-aminoantipyrine were found to be applicable to the simple catalytic system. Furthermore, some practical, unique secondary amides, such as N-arylacrylamides and 4-amido-N-phenylbenzamides, and 4-amino(N-phenyl)antipyrenes, which are difficult to obtain by the classical methods, were prepared.