545380-35-6 Usage
Description
6-Nitro-4-(4-phenoxyphenylethylaMino)quinazoline is a chemical compound characterized by its yellow solid appearance. It is an intermediate in the preparation of NF-κB transcriptional activators, which are significant in various cellular processes, including immune responses and inflammation.
Uses
Used in Pharmaceutical Industry:
6-Nitro-4-(4-phenoxyphenylethylaMino)quinazoline is used as an intermediate for the synthesis of NF-κB transcriptional activators, which play a crucial role in regulating the expression of genes involved in immune and inflammatory responses. Its application in this industry is due to its potential to contribute to the development of new therapeutic strategies for various diseases and conditions.
Used in Research and Development:
In the field of research and development, 6-Nitro-4-(4-phenoxyphenylethylaMino)quinazoline serves as a valuable compound for studying the mechanisms of NF-κB activation and its implications in cellular processes. This understanding can lead to the discovery of novel drug targets and the development of innovative treatments for a range of diseases.
Used in Chemical Synthesis:
6-Nitro-4-(4-phenoxyphenylethylaMino)quinazoline is also utilized in chemical synthesis for the creation of various derivatives and related compounds. Its unique structure and properties make it a versatile building block for the development of new molecules with potential applications in different industries, such as pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 545380-35-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,4,5,3,8 and 0 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 545380-35:
(8*5)+(7*4)+(6*5)+(5*3)+(4*8)+(3*0)+(2*3)+(1*5)=156
156 % 10 = 6
So 545380-35-6 is a valid CAS Registry Number.
545380-35-6Relevant articles and documents
6-amino-4-(4-phenoxyphenylethylamino)quinazoline derivative as well as preparation method and application thereof
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Paragraph 0036; 0043-0044, (2021/01/24)
The invention belongs to the technical field of medicines, and particularly relates to a 6-amino-4-(4-phenoxyphenylethylamino)quinazoline (QNZ) derivative as well as a preparation method and application thereof. According to the invention, a series of QNZ
Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation
Tobe, Masanori,Isobe, Yoshiaki,Tomizawa, Hideyuki,Nagasaki, Takahiro,Takahashi, Hirotada,Fukazawa, Tominaga,Hayashi, Hideya
, p. 383 - 391 (2007/10/03)
We disclose here a new structural class of low-molecular-weight inhibitors of NF-κB activation that were designed and synthesized by starting from quinazoline derivative 6a. Structure-activity relationship (SAR) studies based on 6a elucidated the structural requirements essential for the inhibitory activity toward NF-κB transcriptional activation, and led to the identification of the 6-amino-4-phenethylaminoquinazoline skeleton as the basic framework. In this series of compounds, 11q, containing the 4-phenoxyphenethyl moiety at the C(4)-position, showed strong inhibitory effects on both NF-κB transcriptional activation and TNF-α production. Furthermore, 11q exhibited an anti-inflammatory effect on carrageenin-induced paw edema in rats.
