5454-98-8Relevant articles and documents
Low catalyst loadings for ligand-free copper(I)-oxide-catalyzed N-arylation of methanesulfonamide in water
Tan, Bryan Yong-Hao,Teo, Yong-Chua,Seow, Ai-Hua
, p. 1541 - 1546 (2014/03/21)
A simple and practical protocol for the cross-coupling of methanesulfonamide and aryl iodides under ligand-free copper(I)-oxide-catalyzed conditions in water is reported. The method allows the preparation of a wide variety of synthetically useful N-arylated methanesulfonamides in good to excellent yields (up to 90 %) under the optimized conditions. A convenient and efficient ligand-free method using a copper(I) oxide catalyst at 130 °C in water was developed for the N-arylation of methanesulfonamide with aryl iodides. A variety of functionalized aliphatic and cyclic sulfonamides were coupled with different substituted aryl halides to give the corresponding N-arylated products in good to excellent yields under the optimized conditions. Copyright