545445-10-1

Basic information

• Product Name: 3,3-Dichloro-1-(4-iodophenyl)piperidin-2-one
• Synonyms: 3,3-Dichloro-1-(4-iodophenyl)piperidin-2-one;3,3-Dichloro-1-(4-iodophenyl)-2-piperidinone
• CAS NO: 545445-10-1
• Molecular Formula: C₁₁H₁₀Cl₂INO
• Molecular Weight: 370.01367
• Mol File: 545445-10-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 488.778 °C at 760 mmHg
• Flash Point: 249.404 °C
• Appearance: /
• Density: 1.84
• CAS DataBase Reference: 3,3-Dichloro-1-(4-iodophenyl)piperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-Dichloro-1-(4-iodophenyl)piperidin-2-one(545445-10-1)
• EPA Substance Registry System: 3,3-Dichloro-1-(4-iodophenyl)piperidin-2-one(545445-10-1)

Safety Data

• Hazardous Substances Data: 545445-10-1(Hazardous Substances Data)

Usage

General Description

3,3-Dichloro-1-(4-iodophenyl)piperidin-2-one is a chemical compound with a complex structure that consists of a piperidine ring, iodine, and chlorines. Piperidine, a common organic compound, is a six-membered ring with one nitrogen atom, while the iodophenyl part refers to a phenyl group attached to an iodine atom. The '3,3-dichloro' denote the positions of the two chlorine atoms on the piperidine ring. The '2-one' is indicative of a ketone group also present in the molecule. Despite its complex sounding name and structure, this chemical is often used in scientific and medical research, particularly in synthetic chemistry, and falls under a classification of halogenated organics.

Upstream product

• 385425-15-0 1-(2-oxopiperidin-1-yl)-4-iodobenzene 
• 4509-90-4 5-bromovaleroyl chloride 
• 540-37-4 p-aminoiodobenzene 
• 2067-33-6 5-bromopentanoic acid 

Downstream Products

• 473927-69-4 1-(4-iodo-phenyl)-3-morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one 
• 385425-14-9 1-(4-iodophenyl)-4-(2,2,2-trifluoroacetyl)-piperidine-2,3-dione 
• 543745-11-5 1-(3-cyano-4-fluoro)phenyl-3-trifluoromethyl-6-(4-iodo)phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one 
• 543745-12-6 1-(3-Cyano-4-fluoro)phenyl-3-trifluoromethyl-6-[4-(2-formyl)phenyl]phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one 
• 280118-23-2 BMS-740808 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF APIXABAN

The present invention relates to an improved process for the preparation of Apixaban and its intermediates.

NOVEL PROCESS FOR THE PREPARATION OF A LACTAM-CONTAINING COMPOUND

Provided herein is a novel, commercially viable and industrially advantageous process for the preparation of 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazole-[3,4-c]pyridine-3-carboxamide, in high yield and with high purity, using a novel intermediate 3-chloro-1-(4-iodophenyl)-5,6-dihydropyridin-2(1H)-one.

PYRAZOLE CARBOXAMIDE INHIBITORS OF FACTOR XA

The present invention relates to new pyrazole carboxamide inhibitors of factor Xa, pharmaceutical compositions thereof, and methods of use thereof.