54549-72-3

Basic information

• Product Name: 1-[4-(2-hydroxypropan-2-yl)phenyl]ethanone
• Synonyms: 1-[4-(2-hydroxypropan-2-yl)phenyl]ethanone;4'-(1-Hydroxy-1-methylethyl)acetophenone
• CAS NO: 54549-72-3
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.23
• Mol File: 54549-72-3.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 308.4°C at 760 mmHg
• Flash Point: 130.4°C
• Appearance: /
• Density: 1.056g/cm³
• Vapor Pressure: 0.000295mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.07±0.29(Predicted)
• CAS DataBase Reference: 1-[4-(2-hydroxypropan-2-yl)phenyl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(2-hydroxypropan-2-yl)phenyl]ethanone(54549-72-3)
• EPA Substance Registry System: 1-[4-(2-hydroxypropan-2-yl)phenyl]ethanone(54549-72-3)

Safety Data

• Hazardous Substances Data: 54549-72-3(Hazardous Substances Data)

Usage

General Description

The chemical "1-[4-(2-hydroxypropan-2-yl)phenyl]ethanone" is an organic compound that is also known as "4'-isobutylacetophenone." It is a colorless to pale yellow liquid with a sweet floral odor. 1-[4-(2-hydroxypropan-2-yl)phenyl]ethanone is used as a fragrance ingredient in perfumes and other cosmetics. It is also used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Additionally, it has been studied for its potential as an anti-inflammatory and antioxidant agent. However, it is important to handle this chemical with care, as it may cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C11H14O2/c1-8(12)9-4-6-10(7-5-9)11(2,3)13/h4-7,13H,1-3H3

Upstream product

• 80-15-9 Cumene hydroperoxide 
• 645-13-6 4-isopropylacetophenone 
• 107844-05-3 5-acetyl-3',3'-dimethylbicyclo<3.1.0>hex-3-ene-2-spiro-2'-oxirane 
• 583-05-1 1-phenylpentane-1,4-dione 
• 39575-67-2 (4-(2-methyl-1,3-dioxolan-2-yl)phenyl)magnesium bromide 
• 98-55-5 terpineol 
• 55873-39-7 4-isopropylidenecyclopentenyl methyl ketone 
• 101536-86-1 <4-(1-hydroperoxy-1-methylethyl)-1,3-cyclopentadien-1-yl>-1-ethanone 
• 107856-91-7 6a-acetyl-3,3a,4,6a-tetrahydro-2',2'-dimethyl-spiro 
• 5359-04-6 1-(4-(prop-1-en-2-yl)phenyl)ethan-1-one 
• 3609-53-8 methyl 4-acetylbenzoate 
• 75-16-1 methylmagnesium bromide 
• 917-54-4 methyllithium 
• 586-89-0 4-acetyl-benzoic acid 

Downstream Products

• 5359-04-6 1-(4-(prop-1-en-2-yl)phenyl)ethan-1-one 
• 64253-31-2 1-(2-hydroperoxy-1-methylethyl)-4-acetylbenzene 
• 79506-32-4 1-(1-methyl-1-tert-butylperoxyethyl)-4-acetylbenzene 
• 79506-35-7 1-methyl-1-(4-carboxyphenyl)ethyl tert-butyl peroxide 
• 110726-34-6 4,4'-(1-(4-(2-(4-hydroxy-3-methylphenyl)propan-2-yl)phenyl)ethane-1,1-diyl)bis(2-methylphenol) 
• 110726-28-8 4,4'-(1-(4 (2-(4-hydroxyphenyl)propane-2-yl)phenyl)ethane-1,1-diyl)bis(phenol) 

Relevant articles and documents

Efficient and selective oxidation of tertiary benzylic C[sbnd]H bonds with O2 catalyzed by metalloporphyrins under mild and solvent-free conditions

The direct and efficient oxidation of tertiary benzylic C[sbnd]H bonds to alcohols with O2 was accomplished in the presence of metalloporphyrins as catalysts under solvent-free and additive-free conditions. Based on effective inhibition on the unselective autoxidation and deep oxidation, systematical investigation on the effects of porphyrin ligands and metal centers, and apparent kinetics study, the oxidation system employing porphyrin manganese(II) (T(2,3,6-triCl)PPMn) with bulkier substituents as catalyst, was regarded as the most promising and efficient one. For the typical substrate, the conversion of cumene could reach up to 57.6% with the selectivity of 70.5% toward alcohol, both of them being higher than the current documents under similar conditions. The superiority of T(2,3,6-triCl)PPMn was mainly attributed to its bulkier substituent groups preventing metalloporphyrins from oxidative degradation, its planar structure favoring the interaction between central metal with reactants, and the high efficiency of Mn(II) in the catalytic transformation of hydroperoxides to alcohols.

Non-Heme-Type Ruthenium Catalyzed Chemo- and Site-Selective C?H Oxidation

Herein, we developed a Ru(II)(BPGA) complex that could be used to catalyze chemo- and site-selective C?H oxidation. The described ruthenium complex was designed by replacing one pyridyl group on tris(2-pyridylmethyl)amine with an electron-donating amide ligand that was critical for promoting this type of reaction. More importantly, higher reactivities and better chemo-, and site-selectivities were observed for reactions using the cis-ruthenium complex rather than the trans-one. This reaction could be used to convert sterically less hindered methyne and/or methylene C?H bonds of a various organic substrates, including natural products, into valuable alcohol or ketone products.

Fluoro-Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors

The external quenching method based on flow microreactors allows the generation and use of short-lived fluoro-substituted methyllithium reagents, such as fluoromethyllithium, fluoroiodomethyllithium, and fluoroiodostannylmethyllithium. Highly chemoselective reactions have been developed, opening new opportunities in the synthesis of fluorinated molecules using fluorinated organometallics.