54608-35-4Relevant articles and documents
Psammocindoles A-C: Isolation, Synthesis, and Bioactivity of Indole-γ-lactams from the Sponge Psammocinia vermis
Kwon, Oh-Seok,Ahn, Sungjin,Jeon, Ju-Eun,Park, In Guk,Won, Tae Hyung,Sim, Chung J.,Park, Hyeung-Geun,Oh, Dong-Chan,Oh, Ki-Bong,Noh, Minsoo,Shin, Jongheon
, p. 4667 - 4671 (2021)
Psammocindoles A-C (1-3), a new class of indole alkaloids, were isolated from a Psammocinia vermis sponge. By combined spectroscopic analyses, the structures of these compounds were determined to be the indole-γ-lactams derived from three amino acid residues. In addition, an enantiomer psammocindole D (4), and the N-lactam isomers isopsammocindoles A-D (5-8) were also synthesized. These natural products and synthetic analogues were found to significantly stimulate adiponectin secretion in human bone marrow mesenchymal stem cells.
EIF4E INHIBITORS AND USES THEREOF
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Paragraph 00337; 00364; 00373, (2021/09/11)
The present invention provides compounds inhibiting elF4E activity and compositions and methods of using thereof.
The discovery of new human coagulation factor XIa (FXIa) inhibitors by synthesis, biological evaluation, and structure-based modeling
Lee, Myeong Hwi,Song, Ho Young,Kim, Hyoungrae,Park, Kyung Eun,Kim, Jinyeong,Park, Tae Kyo,Kim, Yong Ju,Kang, Nam Sook
, p. 1105 - 1113 (2016/07/15)
Factor XIa (FXIa) is an enzyme that is activated during the earliest stage of initiation of the intrinsic pathway of the blood coagulation mechanism. In this study, we attempted to discover a new FXIa inhibitor based on structure-based molecular modeling. We found that compound 16 exhibits satisfactory predicted properties while maintaining important binding interactions with FX1a.