54608-52-5

Basic information

• Product Name: PYRAZIN-2-YL-HYDRAZINE
• Synonyms: PYRAZIN-2-YL-HYDRAZINE;2-HYDRAZINOPYRAZINE;2-Hydrazinylpyrazine;Pyrazin-2-yl-hydrazine ,97%;1-(pyrazin-2-yl) hydrazine;2-Hydrazinopyrazine ,97%;1-(pyrazin-2-ylydrazine;2-Hydrazinylpyrazine HCl
• CAS NO: 54608-52-5
• Molecular Formula: C4H6N4
• Molecular Weight: 110.12
• Mol File: 54608-52-5.mol
• Article Data: 28

Chemical Properties

• Melting Point: 109-113℃
• Boiling Point: 307 °C at 760 mmHg
• Flash Point: 139.5 °C
• Appearance: Yellow/Solid
• Density: 1.334 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 5.10±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: PYRAZIN-2-YL-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRAZIN-2-YL-HYDRAZINE(54608-52-5)
• EPA Substance Registry System: PYRAZIN-2-YL-HYDRAZINE(54608-52-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41-36/37/38
• Safety Statements: 26-39-36/37/39
• Hazardous Substances Data: 54608-52-5(Hazardous Substances Data)

Usage

Description

PYRAZIN-2-YL-HYDRAZINE is an organic compound that serves as a key intermediate in the synthesis of various heterocyclic compounds. It is characterized by the presence of a pyrazine ring and a hydrazine functional group, which allows for further chemical reactions and modifications.

Uses

Used in Pharmaceutical Industry:
PYRAZIN-2-YL-HYDRAZINE is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
PYRAZIN-2-YL-HYDRAZINE is used as a starting material in the synthesis of various heterocyclic compounds, such as triazolo[4,3-a]pyrazine 7-oxide, 3-β-D-ribofuranosyl-1,2,4-triazolo[4,3-a]pyrazine, monohydrazones of pyridine, and pyrazine. These synthesized compounds have potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.
Used in Organic Synthesis:
PYRAZIN-2-YL-HYDRAZINE is used as a versatile reagent in organic synthesis, allowing for the formation of various functional groups and complex molecular structures. Its ability to participate in a wide range of chemical reactions makes it a valuable tool for the synthesis of novel compounds with potential applications in various industries.

Upstream product

• 14508-49-7 2-chloropyrazin 

Downstream Products

• 33590-17-9 3-Methyl-s-triazolo<4,3-a>pyrazin 
• 1014632-12-2 ethyl 1-(pyrazin-2-yl)-1H-pyrazole-4-carboxylate 
• 133258-40-9 2-[5-(4-Fluorophenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyrazine 
• 123518-15-0 3-(5-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazolo<4,3-a>pyrazine 
• 58528-48-6 phenyl-pyridin-2-yl-methanone pyrazin-2-ylhydrazone 
• 205443-43-2 2,6-di-tert-butyl-4-(pyrazin-2-ylhydrazonomethyl)phenol 
• 486460-20-2 3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine 
• 274-82-8 [1,2,4]triazolo[4,3-a]pyrazine 
• 717851-32-6 C₁₁H₁₁N₅S 
• 1202233-20-2 methyl[3-methyl-5-phenyl-1-(pyrazin-2-yl)-1H-pyrazol-4-yl]acetate 
• 223743-01-9 C₁₇H₁₄FN₅ 
• 1332301-93-5 3-(4-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyrazine 
• 1393477-72-9 3-[3-[3,5-bis(trifloromoethyl)phenyl]-1H-1,2,4-triazol-1-yl]-N’-(pyrazin-2-yl)acrylohydrazide 

Relevant articles and documents

Synthesis and evaluation of the thiosemicarbazone, dithiocarbazonate, and 2'-pyrazinylhydrazone of pyrazinecarboxaldehyde as agents for the treatment of iron overload

Three prototype tridentate ligands (i.e., pyrazinecarboxaldehyde thiosemicarbazone, sodium pyrazinecarboxaldehyde dithiocarbazonate, and pyrazinecarboxalhyde 2'-pyrazinylhydrazone) were prepared and evaluated for their relative abilities to remove iron from model systems designed to mimic particular aspects of chronic transfusional iron overload. These compounds were synthesized by condensation of pyrazinecarboxaldehyde with the appropriate substituted hydrazide. Iron-binding properties were determined, and the ability to remove iron from from the proteins transferrin and ferritin was ascertained. An in vivo model system employing iron-loaded mice was used to demonstrate that all three compounds were effective at reducing tissue iron levels.

PYRIDINIUM DERIVATIVES AS HERBICIDES

Compounds of the formula (I) (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

Synthesis, bioactivity, action mode and 3D-QSAR of novel anthranilic diamide derivatives

To study the pesticide effect, action mode, structure-activity relationships (SARs) of anthranilic diamide insecticide and screen highly active pesticides, novel anthranilic diamide derivatives were synthesized. Bioassays indicated that all of the title compounds displayed 100% mortality against diamondback moth and oriental armyworm at 100 mg/L, among which 12v and 12w showed 100% insecticidal acitvity at 5 mg/L. Surprisingly compound 12w exhibited better insecticidal acitvity than commercialized chlorantraniliprole against Pyrausta nubilalis (0.1 mg/L) and Cnaphalocrocis Medinalis (2 mg/L). 3D-QSAR and SARs statistical analysis revealed that title compounds with R2 fixed as methoxy had the highest probability possessing high activity. The calcium fluorescence measurements on neurons revealed that E series compounds containing pyrazinyl may have a molecular target different from caffeine on ryanodine receptors rather than the voltage-gated calcium channel present on cytomembran.