5461-52-9

Basic information

• Product Name: N,N-diethylcyclohexanecarboxamide
• Synonyms: Cyclohexanecarboxamide, N,N-diethyl-
• CAS NO: 5461-52-9
• Molecular Formula: C₁₁H₂₁NO
• Molecular Weight: 183.2905
• Mol File: 5461-52-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 284.8°C at 760 mmHg
• Flash Point: 119.6°C
• Density: 0.942g/cm³
• Vapor Pressure: 0.00292mmHg at 25°C
• Refractive Index: 1.472
• CAS DataBase Reference: N,N-diethylcyclohexanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethylcyclohexanecarboxamide(5461-52-9)
• EPA Substance Registry System: N,N-diethylcyclohexanecarboxamide(5461-52-9)

Safety Data

• Hazardous Substances Data: 5461-52-9(Hazardous Substances Data)

Upstream product

• 109-89-7 diethylamine 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 98-89-5 Cyclohexanecarboxylic acid 
• 2043-61-0 cyclohexanecarbaldehyde 
• 3768-61-4 N,N,N',N'-tetraethylthioamine 
• 105398-69-4 Cyclohexanecarboxylic acid 2-thioxo-2H-pyridin-1-yl ester 
• 6667-19-2 benzenenesulfenyl dimethylamine 
• 24398-21-8 N,N-Diethyl-p-chlorbenzolsulfenamid 
• 24398-43-4 N,N-diethyl-S-2-nitrobenzenesulfenamide 
• 221887-36-1 2,2,2-tribromoethyl cyclohexanecarboxylate 
• 931-51-1 cyclohexylmagnesiumchloride 
• 626-62-0 Cyclohexyl iodide 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 38078-09-0 diethylamino-sulfur trifluoride 

Downstream Products

• 90150-05-3 N,N-diethyl-cyclohexylmethylamine 
• 100-49-2 cyclohexylmethyl alcohol 
• 101874-45-7 diethyl-(1-cyclohexyl-2-phenyl-ethyl)-amine 
• 2043-61-0 cyclohexanecarbaldehyde 
• 75115-53-6 (1-chloro-cyclohexyldimethyl)diethylamine 

Relevant articles and documents

Mild and Low-Pressure fac-Ir(ppy)3-Mediated Radical Aminocarbonylation of Unactivated Alkyl Iodides through Visible-Light Photoredox Catalysis

A novel, mild and facile preparation of alkyl amides from unactivated alkyl iodides employing a fac-Ir(ppy)3-catalyzed radical aminocarbonylation protocol has been developed. Using a two-chambered system, alkyl iodides, fac-Ir(ppy)3, amines, reductants, and CO gas (released ex situ from Mo(CO)6), were combined and subjected to an initial radical reductive dehalogenation generating alkyl radicals, and a subsequent aminocarbonylation with amines affording a wide range of alkyl amides in moderate to excellent yields.

Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et 2NSF2]BF4 as a practical cyclodehydration agent

The preparation of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using XtalFluor-E ([Et2NSF2]BF4) as cyclodehydration reagent is described. Various functionalized 1,3,4-oxadiazoles were synthesized and it was found that the use of acetic acid as an additive generally improved the yields.

A direct and mild conversion of tertiary aryl amides to methyl esters using trimethyloxonium tetrafluoroborate: A very useful complement to directed metalation reactions

The scope and generality of a direct process for the conversion of tertiary amides directly to methyl esters has been investigated. The process involves a two-step, one pot procedure in which a tertiary amide is first treated with trimethyloxonium tetrafluoroborate to generate an imidate intermediate which is then hydrolyzed, generally by the addition of saturated aqueous sodium bicarbonate solution. Although this process fails for aliphatic amides, very good yields are realized for a variety of amides derived from aromatic carboxylic acids. Steric hindrance at the N-alkyl group is well tolerated; thus N,N-dimethyl, -diethyl, and -diisopropyl amides can all be utilized successfully. (C) 2000 Elsevier Science Ltd.