5462-66-8

Basic information

• Product Name: 4-[2-(4-methoxyphenyl)ethyl]pyridine
• CAS NO: 5462-66-8
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.275
• Mol File: 5462-66-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 325.9°C at 760 mmHg
• Flash Point: 119.4°C
• Density: 1.065g/cm³
• Vapor Pressure: 0.000423mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 4-[2-(4-methoxyphenyl)ethyl]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(4-methoxyphenyl)ethyl]pyridine(5462-66-8)
• EPA Substance Registry System: 4-[2-(4-methoxyphenyl)ethyl]pyridine(5462-66-8)

Safety Data

• Hazardous Substances Data: 5462-66-8(Hazardous Substances Data)

Usage

Class

Pyridine derivative

Use

Building block in the synthesis of bioactive compounds in the pharmaceutical industry

Structure

Methoxyphenyl moiety and ethyl group attached to the pyridine ring

Pharmacological activities

Anti-inflammatory and analgesic properties

Potential applications

Anti-cancer and anti-infective agent

Versatility

Valuable compound for drug development and research in medicine and pharmaceuticals

Upstream product

• 108-89-4 picoline 
• 768-90-1 1-Adamantyl bromide 
• 722-21-4 (E)-4-(4-methoxystyryl)pyridine 
• 105-13-5 4-Methoxybenzyl alcohol 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 13258-63-4 4-(2-Aminoethyl)pyridine 
• 100-43-6 4-vinylpyridine 
• 100-66-3 methoxybenzene 
• 872-85-5 pyridine-4-carbaldehyde 

Downstream Products

• 263872-14-6 1-(4-hydroxyphenyl)-2-(4-pyridyl)ethane 

Relevant articles and documents

Construction of α-Amino Azines via Thianthrenation-Enabled Photocatalyzed Hydroarylation of Azine-Substituted Enamides with Arenes

α-Amino azines are widely found in pharmaceuticals and ligands. Herein, we report a practical method for accessing this class of compounds via photocatalyzed hydroarylation of azine-substituted enamides with the in situ-generated aryl thianthrenium salts as the radical precursor. This reaction features a broad substrate scope, good functional group tolerance, and mild conditions and is suitable for the late-stage installation of α-amino azines in complex structures.

Iridium-Catalyzed C-Alkylation of Methyl Group on N-Heteroaromatic Compounds using Alcohols

In this study, we developed a catalytic system for the C-alkylation of a methyl group on N-heteroaromatic compounds, including pyridine, pyrimidine, pyrazine, quinoline, quinoxaline, and isoquinoline, using alcohols based on a hydrogen-borrowing process with [Cp*IrCl2]2 (Cp*: η5-pentamethylcyclopentadienyl) combined with potassium t-butoxide and 18-crown-6-ether as the catalyst precursor.

Catalytic alkylation of methyl-N-heteroaromatics with alcohols

(Chemical Equation Presented) A novel catalytic C-C coupling reaction in which N-heteroaromatic-substituted methyl groups are efficiently alkylated using primary alcohols is introduced. The synthesis protocol is based on iridium catalysts and most likely relies on the borrowing hydrogen or hydrogen autotransfer mechanism. A variety of substrate combinations can readily be employed in this reaction, including pyrimidines, pyrazines, pyridazines, and even fairly activated 2- and 4-picolines. Copyright