54623-25-5 Usage
Description
2,3,5-Tri-O-benzyl-D-ribose is a synthetically modified sugar molecule derived from D-ribose, a naturally occurring pentose sugar. It is characterized by the presence of three benzyl groups attached to the 2nd, 3rd, and 5th hydroxyl groups, which significantly alter its chemical properties and reactivity. This modification enhances its stability and solubility in organic solvents, making it a versatile compound for various applications in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
2,3,5-Tri-O-benzyl-D-ribose is used as a pharmaceutical intermediate for the synthesis of various biologically active compounds. Its unique structural features allow it to serve as a key building block in the development of novel drugs targeting specific receptors or enzymes.
Used in Chemical Synthesis:
2,3,5-Tri-O-benzyl-D-ribose is used as a synthetic intermediate for the preparation of complex organic molecules, particularly in the field of medicinal chemistry. Its benzyl-protected hydroxyl groups facilitate selective reactions and protect the sugar moiety from unwanted side reactions, making it an ideal candidate for the synthesis of targeted therapeutic agents.
Used in Research and Development:
2,3,5-Tri-O-benzyl-D-ribose is employed as a research tool in the study of carbohydrate chemistry, biochemistry, and molecular biology. Its unique structural properties enable researchers to investigate the role of sugar moieties in various biological processes and their interactions with proteins, lipids, and nucleic acids.
Used in Allosteric Modulation:
2,3,5-Tri-O-benzyl-D-ribose is used as an allosteric enhancer of agonist activity at the A1 adenosine receptor. This application highlights its potential in the development of new therapeutic strategies for conditions such as asthma, chronic obstructive pulmonary disease (COPD), and other respiratory disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 54623-25-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,6,2 and 3 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 54623-25:
(7*5)+(6*4)+(5*6)+(4*2)+(3*3)+(2*2)+(1*5)=115
115 % 10 = 5
So 54623-25-5 is a valid CAS Registry Number.
InChI:InChI=1/C26H28O5/c27-16-25(30-18-22-12-6-2-7-13-22)26(31-19-23-14-8-3-9-15-23)24(28)20-29-17-21-10-4-1-5-11-21/h1-16,24-26,28H,17-20H2/t24-,25+,26-/m1/s1
54623-25-5Relevant articles and documents
Oligonucleotides comprising a modified or non-natural nucleobase
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, (2008/06/13)
One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitroindolyl, nitropyrrolyl, or nitroimidazolyl. In a preferred embodiment, the non-natural nucleobase is difluorotolyl. In certain embodiments, only one of the two oligonucleotide strands comprising the double-stranded oligonucleotide contains a non-natural nucleobase. In certain embodiments, both of the oligonucleotide strands comprising the double-stranded oligonucleotide independently contain a non-natural nucleobase. In certain embodiments, the oligonucleotide strands comprise at least one modified sugar moiety. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one non-natural nucleobase. In a preferred embodiment, the non-natural nucleobase is difluorotolyl. In certain embodiments, the ribose sugar moiety that occurs naturally in nucleosides is replaced with a hexose sugar, polycyclic heteroalkyl ring, or cyclohexenyl group. In certain embodiments, at least one phosphate linkage in the oligonucleotide has been replaced with a phosphorothioate linkage.
