54629-30-0

Basic information

• Product Name: 10H-[1]Benzopyrano[3,2-c]pyridin-10-one
• Synonyms: 10H-[1]Benzopyrano[3,2-c]pyridin-10-one
• CAS NO: 54629-30-0
• Molecular Formula: C₁₂H₇NO₂
• Molecular Weight: 197.19
• Mol File: 54629-30-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 184 °C
• Boiling Point: 380.6±11.0 °C(Predicted)
• Appearance: /
• Density: 1.342±0.06 g/cm3(Predicted)
• PKA: 3.70±0.20(Predicted)
• CAS DataBase Reference: 10H-[1]Benzopyrano[3,2-c]pyridin-10-one(CAS DataBase Reference)
• NIST Chemistry Reference: 10H-[1]Benzopyrano[3,2-c]pyridin-10-one(54629-30-0)
• EPA Substance Registry System: 10H-[1]Benzopyrano[3,2-c]pyridin-10-one(54629-30-0)

Safety Data

• Hazardous Substances Data: 54629-30-0(Hazardous Substances Data)

Upstream product

• 54629-95-7 4-phenoxy-nicotinic acid 
• 110523-74-5 2-benzyl-1,2,3,4,5,6,7,8-octahydro-2-azaxanthone 
• 119755-39-4 2-((E)-2-Dimethylamino-vinyl)-4-oxo-4H-chromene-3-carbaldehyde 
• 116922-74-8 (4-fluoro-3-pyridyl)-2-methoxyphenylmethanone 
• 93598-98-2 trans-1-Dimethylamino-3-(4-oxo-4H-1-benzopyran-3-yl)-3-oxopropene 
• 17422-75-2 3-acetyl-4H-chromen-4-one 
• 694-52-0 4-fluoropyridine 
• 116922-70-4 (4-fluoro-3-pyridyl)-2-methoxyphenylmethanol 
• 135-02-4 ortho-anisaldehyde 
• 55168-31-5 2-methyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde 
• 119755-20-3 2-methyl-4-oxochromene-3-carbaldehyde dimethylhydrazone 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 53234-67-6 4-(1-phenylmethyl-1,2,5,6-tetrahydro-4-pyridyl)morpholine 
• 132038-28-9 4-phenoxy-3-pyridinamine 

Relevant articles and documents

Synthesis of azafluorenones and related compounds using deprotocupration-aroylation followed by intramolecular direct arylation

The efficiency of the deprotocupration-aroylation of 2-chloropyridine using lithiocuprates prepared from CuX (X=Cl, Br) and LiTMP (TMP=2,2,6,6- tetramethylpiperidido, 2 equiv) was investigated. CuCl was identified as a more suitable copper source than CuBr for this purpose. Different diaryl ketones bearing a halogen at the 2 position of one of the aryl groups were synthesized in this way from azines and thiophenes. These were then involved in palladium-catalyzed ring closure: substrates underwent expected CH-activation-type arylation to afford fluorenone-type compounds, and were also subjected to cyclization reactions leading to xanthones, notably in the presence of oxygen-containing substituents or reagents.

Intramolecular Anionic Friedel-Crafts Equivalents. A General Regiospecific Route to Substituted and Naturally Occurring Xanthen-9-ones

An LDA-induced regiospecific and general conversion of diaryl ether 2-carboxamides 4 into substituted xanthones 5, including natural products, 2-hydroxy-1-methoxyxanthone (8) and 6-deoxyjacareubin (14), is described.

Directed Lithiation of 4-Halopyridines: Chemoselectivity, Regioselectivity and Application to Synthesis

4-Chloro and 4-fluoropyridines were ortho-lithiated by n-butyllithium-TMEDA chelate or lithium diisopropylamide at low temperature.The resulting 3-lithio 4-halopyridines were reacted with electrophiles which led to various 3,4-disubstituted pyridines.The versatility of this functionalization is enhanced by the 4-halogen reactivity towards nucleophiles such as water, methylate and amines.Some of the 3,4-disubstituted synthons were annelated to naphthyridine, xanthone and coumarin or condensed to Hantzsch-ester or to "chlotrimazol" analogues.Lithiation of 4-fluoropyridine led in one step to 3,4-pyridyne, which was trapped by cycloaddition with furans.