54642-23-8 Usage
Description
JNK Inhibitor II, Negative Control is a methylated analog of JNK Inhibitor II, which is characterized by its lower affinity for JNK2 and JNK3. It serves as a useful negative control in various kinase assays due to its reduced potency compared to the original compound, SP600125.
Usage:
Used in Research Applications:
JNK Inhibitor II, Negative Control is used as a negative control agent for [application reason] in various kinase assays. It is particularly useful in experiments where a comparison is needed between the effects of the active compound and a non-active or less active compound.
Used in Pharmaceutical Industry:
JNK Inhibitor II, Negative Control is used as a research tool for [application reason] in the development of new drugs targeting the JNK pathway. Its lower affinity for JNK2 and JNK3 allows researchers to study the specific effects of JNK inhibition without significant interference from the negative control compound.
Used in Cell Signaling Studies:
JNK Inhibitor II, Negative Control is used as a control substance for [application reason] in cell signaling studies, particularly those focusing on the JNK pathway. It helps researchers understand the role of JNK in cellular processes and identify potential therapeutic targets for various diseases.
Biochem/physiol Actions
Target IC50: 18 μM and 24 μM against JNK2 and JNK3, respectively
Check Digit Verification of cas no
The CAS Registry Mumber 54642-23-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,6,4 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 54642-23:
(7*5)+(6*4)+(5*6)+(4*4)+(3*2)+(2*2)+(1*3)=118
118 % 10 = 8
So 54642-23-8 is a valid CAS Registry Number.
54642-23-8Relevant articles and documents
Alkyl chain substituted 1,9-pyrazoloanthrones exhibit prominent inhibitory effect on c-Jun N-terminal kinase (JNK)
Prasad, Karothu Durga,Trinath, Jamma,Biswas, Ansuman,Sekar, Kanagaraj,Balaji, Kithiganahalli N.,Guru Row, Tayur N.
supporting information, p. 4656 - 4662 (2014/06/24)
N-Alkyl substituted pyrazoloanthrone derivatives were synthesized, characterized and tested for their in vitro inhibitory activity over c-Jun N-terminal kinase (JNK). Among the tested molecules, a few derivatives showed significant inhibitory activity against JNK with minimal off-target effect on other mitogen-activated protein kinase (MAP kinase) family members such as MEK1/2 and MKK3,6. These results suggested that N-alkyl (propyl and butyl) bearing pyrazoloanthrone scaffolds provide promising therapeutic inhibitors for JNK in regulating inflammation associated disorders. This journal is
N-tert-butoxycarbonyl-N-substituted hydrazines in S(N)Ar displacements. Synthetic pathways to N-1-substituted anthrapyrazoles, aza-anthrapyrazoles and aza-benzothiopyranoindazoles
Oliva, Ambrogio,Ellis, Michael,Fiocchi,Menta, Ernesto,Krapcho, A. Paul
, p. 47 - 55 (2007/10/03)
The synthesis of several N-tert-butoxycarbonyl(Boc)-protected-N- substituted hydrazines has been accomplished. The use of these protected hydrazines in S(N)Ar substitutions leads to products in which the most nucleophilic nitrogen displaces the leaving group. Treatment of these compounds with trifluoroacetic acid readily removes the Boc-protecting group and the intermediates readily undergo cyclizations to yield N-1-substituted aza-benzothiopyranoindazoles, anthrapyrazoles and aza-anthrapyrazoles. Side chain buildup was employed in the synthesis of several aza-anthrapyrazoles.
