5465-11-2Relevant articles and documents
A facile synthesis of 3,4-disubstituted-1,2-dihydro-5H-pyrrol-2-ones
Bhandari, Kalpana,Sharma
, p. 2467 - 2470 (2007/10/03)
A facile and efficient method for the synthesis of 3,4-disubstituted-1,2- dihydro-5H-pyrrol-2-ones 8a,c-f is reported. The method involves the hydrogenation of cyanohydrins of 2-alkyl-3-oxobutyric acid alkyl esters 1a-f, over Raney Ni at 50 psi to furnish hitherto unknown aminoacetyl intermediates 6a-f in quantitative yields which are cyclised to the targeted compounds.