5465-67-8

Basic information

• Product Name: NSC25824
• Synonyms: NSC25824;(Tosylamino)acetic acid ethyl ester;2-(Tosylamino)acetic acid ethyl ester;2-[(4-Methylphenyl)sulfonylamino]acetic acid ethyl ester;Glycine, N-[(4-Methylphenyl)sulfonyl]-, ethyl ester;N-[(4-Methylphenyl)sulfonyl]-, ethyl ester;ETHYL N-P-TOLYLSULFONYL-GLYCINATE
• CAS NO: 5465-67-8
• Molecular Formula: C₁₁H₁₅NO₄S
• Molecular Weight: 257.3061
• Mol File: 5465-67-8.mol
• Article Data: 23

Chemical Properties

• Melting Point: 64-66 °C
• Boiling Point: 384.7°Cat760mmHg
• Flash Point: 186.5°C
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 4.02E-06mmHg at 25°C
• Refractive Index: 1.525
• PKA: 9.25±0.50(Predicted)
• CAS DataBase Reference: NSC25824(CAS DataBase Reference)
• NIST Chemistry Reference: NSC25824(5465-67-8)
• EPA Substance Registry System: NSC25824(5465-67-8)

Safety Data

• Hazardous Substances Data: 5465-67-8(Hazardous Substances Data)

Usage

General Description

NSC25824 is a chemical compound known for its biological activity related to cell migration. It is primarily recognized as an inhibitor of the Dedicator of Cytokinesis 1 (DOCK1) protein, which plays a significant role in cellular processes such as growth, differentiation, and migration. By inhibiting DOCK1, NSC25824 can potently inhibit cell migration, making it a potential therapeutic target for diseases involving abnormal cell migration, such as cancer. Despite this potential, more studies are needed to fully understand the mechanism and effects of NSC25824.

InChI:InChI=1/C11H15NO4S/c1-3-16-11(13)8-12-17(14,15)10-6-4-9(2)5-7-10/h4-7,12H,3,8H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 1080-44-0 N-Tosylglycine 
• 29981-92-8 1-tosyl-3-methyl-imidazolium chloride 
• 459-73-4 GlyOEt*HCl 
• 89367-43-1 1-tosyl-3,4,4,5,5-pentamethyl-Δ²-imidazolinium iodide 
• 51060-12-9 1-tosyl-2,3-dimethylimidazolium chloride 
• 623-33-6 glycine ethyl ester hydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 14694-46-3 3,5-di-tert-butyl-4-hydroxyphenyl 4-methylbenzenesulfonate 
• 941-55-9 4-toluenesulfonyl azide 
• 18295-66-4 1-ethoxy-1-(trimethylsiloxy)ethene 
• 83670-53-5 ethyl (N-tosylimino)acetate 
• 742-25-6 2,4-dinitrophenyl 4-methylbenzenesulfonate 
• 89367-42-0 1-tosyl-4,4,5,5-tetramethyl-Δ²-imidazoline 

Downstream Products

• 92198-69-1 N-tert-butyl-N-(toluene-4-sulfonyl)-glycine 
• 3619-20-3 p-methylphenylsulfonylaminoacetic acid hydrazide 
• 138163-82-3 3-Hydroxy-5-methyl-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 138163-78-7 3-Hydroxy-4-methyl-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 82355-12-2 [Ethoxycarbonylmethyl-(toluene-4-sulfonyl)-amino]-acetic acid benzyl ester 
• 106119-73-7 N,N'-Bis(N-tosylethoxycarbonylmethylaminomethyl)diaza-18-crown-6 
• 3284-52-4 ethyl 3-hydroxy-3-methyl-1-p-toluenesulfonylpyrrolidine-2-carboxylate 
• 138163-85-6 3-Hydroxy-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 2949-22-6 Glycine ethyl ester isocyanate 
• 882513-24-8 [((E)-4-Cyclopropyl-but-3-enyl)-(toluene-4-sulfonyl)-amino]-acetic acid ethyl ester 

Relevant articles and documents

Ligand-Enabled Copper-Catalyzed N-Alkynylation of Sulfonamide with Alkynyl Benziodoxolone: Synthesis of Amino Acid-Derived Ynamide

Ynamides are versatile building blocks in organic synthesis. However, the synthesis of amino acid-derived ynamides is difficult but in high demand. Herein, we disclose the copper-catalyzed Csp-N coupling of sulfonamide, including amino acid and peptide derivatives, to give ynamides by using alkynyl benziodoxolones with broad functional group tolerance under mild reaction conditions. The electron-rich bipyridine as a ligand and ethanol as solvent were used for the success of this reaction. The usefulness of the obtained amino acid-derived ynamide as building block was showcased by further derivatization to unique amino acid derivatives. A control experiment to elucidate the mechanistic insight was also described.

1,7-naphthyridine derivative, preparation method and applications thereof

The present invention relates to a compound represented by a formula (I) or a tautomer, an optical isomer, a nitrogen oxide, a solvate, a pharmaceutically acceptable salt or a prodrug thereof, a preparation method of the compound, a pharmaceutical composi

A α-cycloalanine on the preparation method

The invention relates to a method for synthesizing alpha-cycloalanine. The method comprises the steps of performing esterification on glycine serving as a raw material, synthesizing esterified product from the former step with p-benzene sulfonyl chloride, performing alkylation reaction on the synthesized product from the former step and 1,2-dibromoethane, and finally hydrolyzing to obtain a product. The method has the advantages of low process pollution, high yield, good purity, low cost and the like, is simple to operate and is a process suitable for industrialized production.