5465-98-5

Basic information

• Product Name: (2-nitrophenyl)cyanamide
• CAS NO: 5465-98-5
• Molecular Formula: C₇H₅N₃O₂
• Molecular Weight: 163.1335
• Mol File: 5465-98-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 282.6°C at 760 mmHg
• Flash Point: 124.7°C
• Density: 1.429g/cm³
• Vapor Pressure: 0.00333mmHg at 25°C
• Refractive Index: 1.663
• CAS DataBase Reference: (2-nitrophenyl)cyanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2-nitrophenyl)cyanamide(5465-98-5)
• EPA Substance Registry System: (2-nitrophenyl)cyanamide(5465-98-5)

Safety Data

• Hazardous Substances Data: 5465-98-5(Hazardous Substances Data)

Usage

General Description

(2-nitrophenyl)cyanamide is a chemical compound that consists of a nitrophenyl group and a cyanamide group. It is a yellow crystalline solid that is sparingly soluble in water. (2-nitrophenyl)cyanamide is primarily used as a building block in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals. It is also utilized as a reagent in organic reactions, such as the formation of heterocyclic compounds. Due to its potentially hazardous nature, proper safety precautions should be taken when handling (2-nitrophenyl)cyanamide, including the use of personal protective equipment and working in a well-ventilated area.

Upstream product

• 51039-84-0 N-(2-nitrophenyl)thiourea 
• 506-68-3 bromocyane 
• 88-74-4 2-nitro-aniline 
• 5461-83-6 N-nitro-N'-phenyl-guanidine 
• 2719-30-4 o-nitrophenylisothiocyanate 
• 62-53-3 aniline 
• 420-04-2 CYANAMID 
• 609-73-4 o-nitroiodobenzene 

Downstream Products

• 2273-04-3 1-(2-nitrophenyl)urea 
• 92151-68-3 benzoyl-(2-nitro-phenyl)-carbamonitrile 

Relevant articles and documents

Iron-mediated desulphurization approach: synthesis of cyanamides and their conversions

The iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology. All the reactions are rapid, facile, and accomplished at room temperature. A variety of substrates readily underwent the optimized reaction conditions to provide their respective target products in good to excellent yields. Furthermore, we have confirmed that no other by-products could be identified during our experimental reaction process. Graphical abstract: Iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology.[Figure not available: see fulltext.].

The synthesis of aryl cyanamides through C-N cross-coupling

The methodology for the preparation of aromatic cyanamides has been demonstrated. The present method involves consecutive desulphurization/C-N cross-coupling reaction. Cheap, readily available and air stable cobalt catalyst has been used for this methodology. In addition, the substrate scope has been explored.

One-pot three-component tandem reaction: Synthesis of aryl/alkyl cyanamides libraries and their further conversion into tetrazole derivatives

We have developed methodology for the synthesis of aryl/alkyl cyanamides from amines in one-pot four steps reaction using cheap, readily available and air stable copper source as catalyst under mild reaction conditions. We have also studied the application of cyanamides. In this connection, we could construct aryl tetrazolamine from cyanamides using click reaction.