54651-57-9

Basic information

• Product Name: HEMOGLOBIN-A0
• Synonyms: HEMOGLOBIN-A0;HEMOGLOBIN-A0, FERROUS;hemoglobin a0, ferrous stabilized human;HEMOGLOMIN A(O));haemoglobin AO, ferrous;Hemoglobin A0, Ferrous Stabilized
• CAS NO: 54651-57-9
• Molecular Weight: 0
• EINECS: 259-278-9
• Product Categories: HemoglobinApplication Index;Plasma&Blood Proteins;Plasma, Blood, and Related Proteins and Reagents;Serum Proteins;Serum Proteins and Related Enzymes
• Mol File: 54651-57-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: −20°C
• Solubility: H2O: soluble20mg/mL
• CAS DataBase Reference: HEMOGLOBIN-A0(CAS DataBase Reference)
• NIST Chemistry Reference: HEMOGLOBIN-A0(54651-57-9)
• EPA Substance Registry System: HEMOGLOBIN-A0(54651-57-9)

Safety Data

• Hazard Codes: B
• WGK Germany: 3
• Hazardous Substances Data: 54651-57-9(Hazardous Substances Data)

Usage

Description

Hemoglobin A0, also known as normal adult hemoglobin, is a type of hemoglobin found in red blood cells. It is responsible for the red color of these cells and plays a crucial role in the transportation of oxygen from the lungs to body tissues and the return transport of carbon dioxide.

Uses

Used in Medical Research:
Hemoglobin A0 is used as a non-fluorescent absorber in the preparation of tissue-mimicking phantoms, which are essential for studying various medical conditions and imaging techniques.
Used in Cardiovascular Research:
Hemoglobin A0 is employed to investigate how coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype, which is important for understanding the development and progression of atherosclerosis.
Used in Hemoglobinopathy Research:
Hemoglobin A0 is used to study the interference of hemoglobin (Hb) A0, HbA2, and HbS in the assay of HbF, which is crucial for diagnosing and managing hemoglobinopathies such as sickle cell anemia and thalassemia.
Used in Pharmaceutical Industry:
Hemoglobin A0 is used as a reference material for the development and validation of diagnostic tests and assays related to hemoglobinopathies and other blood disorders.
Used in Biomedical Engineering:
Hemoglobin A0 is utilized in the development of oxygen-carrying blood substitutes and artificial blood products, which can be used in situations where blood transfusions are not possible or are limited.

Biochem/physiol Actions

Variation in the haemoglobin (Hb) encoding genes results in haemoglobinopathies such as thalassaemia and atypical structural variants like Hb Lepore and HbE.