54672-44-5

Basic information

• Product Name: 4-(2,2-DIFLUOROCYCLOPROPYL)-TOLUENE
• Synonyms: 4-(2,2-DIFLUOROCYCLOPROPYL)-TOLUENE
• CAS NO: 54672-44-5
• Molecular Formula: C₁₀H₁₀F₂
• Molecular Weight: 168.18
• Mol File: 54672-44-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 206.2 °C at 760 mmHg
• Flash Point: 63.2 °C
• Appearance: /
• Density: 1.13 g/cm³
• Vapor Pressure: 0.345mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 4-(2,2-DIFLUOROCYCLOPROPYL)-TOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,2-DIFLUOROCYCLOPROPYL)-TOLUENE(54672-44-5)
• EPA Substance Registry System: 4-(2,2-DIFLUOROCYCLOPROPYL)-TOLUENE(54672-44-5)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 54672-44-5(Hazardous Substances Data)

Usage

General Description

4-(2,2-Difluorocyclopropyl)-toluene is a chemical compound with the molecular formula C10H9F2. It is a substituted toluene with two fluorine atoms and a cyclopropyl group attached to the benzene ring. 4-(2,2-Difluorocyclopropyl)-toluene is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical intermediates. It is also used in chemical research and as a reagent in organic synthesis. Additionally, 4-(2,2-Difluorocyclopropyl)-toluene has potential applications in the development of new materials and as a precursor for the production of specialty chemicals. Its unique structure and properties make it a valuable molecule for various scientific and industrial applications.

InChI:InChI=1/C10H10F2/c1-7-2-4-8(5-3-7)9-6-10(9,11)12/h2-5,9H,6H2,1H3

Upstream product

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Relevant articles and documents

Palladium-catalyzed allylic alkylation dearomatization of β-naphthols and indoles withgem-difluorinated cyclopropanes

A palladium-catalyzed allylic alkylation dearomatization of β-naphthols and indoles withgem-difluorinated cyclopropanes has been developed. This reaction provided an efficient route to access 2-fluoroallylic β-naphthalenones and indolenines bearing quaternary carbon centers in good yields with highZ-selectivityviaC-C bond activation, C-F bond cleavage and the dearomatization process, benefiting from the wide substrate scope and good functional group tolerance. Moreover, 2-fluoroallylic furanoindoline and pyrroloindolines were achieved in good efficiencyviacascade allylic alkylation, dearomatization and cyclization processes in the presence of Et3B.

Palladium-Catalyzed Defluorinative Alkylation of gem-Difluorocyclopropanes: Switching Regioselectivity via Simple Hydrazones

Conventional approaches for Pd-catalyzed ring-opening cross-couplings of gem-difluorocyclopropanes with nucleophiles predominantly deliver the β-fluoroalkene scaffolds (linear selectivity). Herein, we report a cooperative strategy that can completely switch the reaction selectivity to give the alkylated α-fluoroalkene skeletons (branched selectivity). The unique reactivity of hydrazones that enables analogous inner-sphere 3,3′-reductive elimination driven by denitrogenation, as well as the assistance of steric-embedded N-heterocyclic carbene ligand, are the key to switch the regioselectivity. A wide range of hydrazones derived from naturally abundant aryl and alkyl aldehydes are well applicable, and various gem-difluorocyclopropanes, including modified pharmaceutical and biological molecules, can be efficiently functionalized with high value alkylated α-fluorinated alkene motifs under mild conditions.

Model II fluorine asia [...] inner salt synthesis and its application

The present invention provides synthesis and application of difluoro methylene phosphorus inner salt, wherein the compound has a structure shown in Formula A: (R1R2R3)P+CF2CO2 -. The definitions of substituent groups are described in the specification. Th