54675-30-8

Basic information

• Product Name: 1-Ethyl-4-hydroxy-2(1H)-quinolinone
• Synonyms: 1-Ethyl-4-hydroxy-2(1H)-quinolinone;1-ethyl-4-hydroxy-1,2-dihydroquinolin-2-one;1-Ethyl-4-hydroxy-1H-quinolin-2-one
• CAS NO: 54675-30-8
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21
• Mol File: 54675-30-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 255-264 °C(Solv: ethanol (64-17-5))
• Boiling Point: 307.6°C at 760 mmHg
• Flash Point: 139.8°C
• Appearance: /
• Density: 1.264g/cm³
• Vapor Pressure: 0.000311mmHg at 25°C
• Refractive Index: 1.62
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: 1-Ethyl-4-hydroxy-2(1H)-quinolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Ethyl-4-hydroxy-2(1H)-quinolinone(54675-30-8)
• EPA Substance Registry System: 1-Ethyl-4-hydroxy-2(1H)-quinolinone(54675-30-8)

Safety Data

• Hazardous Substances Data: 54675-30-8(Hazardous Substances Data)

Usage

Type

Synthetic derivative of quinoline

Applications

Pharmaceutical and cosmetic products

Properties

Antioxidant and antimicrobial

Activities

Antifungal, antibacterial, and antiviral

Uses

Topical creams, ointments, and lotions

Potential applications

Treatment of skin conditions, preservative in personal care products

Research status

Further research needed to understand potential health effects and safety profile

InChI:InChI=1/C11H11NO2/c1-2-12-9-6-4-3-5-8(9)10(13)7-11(12)14/h3-7,14H,2H2,1H3

Upstream product

• 66134-57-4 3-acetyl-1-ethyl-4-hydroxy-2(1Η)-quinolinone 
• 405112-23-4 4-hydroxy-2-oxo-1-ethyl-1,2-dihydroquinoline-3-carboxylic acid 
• 103-69-5 N-ethyl-N-phenylamine 
• 1663-67-8 malonoyl dichloride 
• 161185-28-0 6-ethyl-4-hydroxy-2,5-dioxo-5,6-dihydro-2H-pyrano[3,2-c]quinoline 
• 331963-41-8 C₁₉H₁₇N₃O₄ 
• 105-53-3 diethyl malonate 

Downstream Products

• 1005133-44-7 C₂₂H₂₀ClNO₃ 
• 1005133-40-3 C₂₂H₂₁NO₃ 
• 1005133-45-8 C₂₃H₂₂ClNO₃ 

Relevant articles and documents

4-Hydroxyquinol-2-ones. 87. Unusual synthesis of 1-R-4-hydroxy-1-oxo-1,2- dihydroquinoline-3-carboxylic acid pyridylamides

4-Chloro-2-oxo-1,2-dihydroquinoline-3-carboxylic acids and their esters react with aminopyridines in refluxing DMF to give the corresponding 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid pyridylamides. Their structures were proved by 1

Synthesis of new quinolinones from 3-nitropyranoquinolinones

Alkaline hydrolysis of 3-nitropyranoquinolinones (6-alkyl-4-hydroxy-3-nitro-2H-pyrano[3,2-c]quinoline-2,5(6H)-diones) for different reaction times gave five products which were formed by the progressive degradation of the nitropyrano ring. Varying amounts of 3-nitroacetylquinolinones, quinolinones with side-chains of β- And β-ketoacids, quinolinone-3-carboxylic acids and 4-hydroxyquinolinones were isolated. With the aim of preparing new biologically active quinolone derivatives, the products of reaction of the 3-nitropyranoquinolinones with side-chains of α- And β-ketoacids with some nitrogen and carbon nucleophiles were also studied, some giving rise to annulated products.

4-Hydroxy-2-quinolones. 149*. Synthesis, chemical transformations, and biological properties of β-N-acylhydrazides of 1-R-4-hydroxy-2-oxo-1,2- dihydro-quinoline-4-carboxylic acids

Two methods of preparation have been proposed and the synthesis has been effected of a large series of β-N-acylhydrazides of 1-R-4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxylic acids. The possibility of using various condensing agents for converting them into the corresponding 1,3,4-oxa-diazoloquinolines has been studied. Results are given of an investigation of the antitubercular activity of the synthesized compounds.