5468-74-6

Basic information

• Product Name: 2-(2-bromobenzyl)-4-methylphenol
• CAS NO: 5468-74-6
• Molecular Formula: C₁₄H₁₃BrO
• Molecular Weight: 277.1564
• Mol File: 5468-74-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 373.9°C at 760 mmHg
• Flash Point: 179.9°C
• Density: 1.387g/cm³
• Vapor Pressure: 4.03E-06mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 2-(2-bromobenzyl)-4-methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromobenzyl)-4-methylphenol(5468-74-6)
• EPA Substance Registry System: 2-(2-bromobenzyl)-4-methylphenol(5468-74-6)

Safety Data

• Hazardous Substances Data: 5468-74-6(Hazardous Substances Data)

Usage

General Description

2-(2-bromobenzyl)-4-methylphenol, also known as 2-bromo-4-methyl-6-phenylphenol, is an organic compound with the chemical formula C14H13BrO. It is a phenolic compound with a bromine atom and a benzyl group attached to a phenol ring. This chemical is commonly used as an antiseptic and disinfectant due to its strong antimicrobial properties. It is often found in various commercial products such as soaps, lotions, and creams. Additionally, it has been studied for potential applications in the treatment of bacterial and fungal infections. However, its use and production are regulated due to its potential environmental and health effects.

Upstream product

• 106-44-5 p-cresol 
• 578-51-8 2-bromobenzylchloride 
• 6279-34-1 1-bromo-2-((p-tolyloxy)methyl)benzene 
• 95-46-5 2-methylphenyl bromide 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 

Downstream Products

• 850355-22-5 1-Benzyloxy-2-(2-bromo-benzyl)-4-methyl-benzene 
• 791821-95-9 4-methyl-2-[(2-formylphenyl)methyl]phenol 
• 791821-94-8 4-methyl-2-[(2-cyanophenyl)methyl]phenol 
• 850355-33-8 2-(2-benzyloxy-5-methyl-benzyl)-benzonitrile 

Relevant articles and documents

Intramolecular 9-membered hydrogen bonding of 2-arylmethylphenols having carbonyl groups at 2′-position

Thermodynamic parameters of nine-membered intramolecular hydrogen bonding between carbonyl groups and phenolic hydroxyl groups of 2-arylmethylphenols having methoxycarbonyl, dimethylcarbamoyl, and formyl groups were determined by variable temperature 1H NMR studies and van't Hoff analysis. The enthalpy of the hydrogen bonding was related to the electron-withdrawing ability of the substituents on the phenol and the basicity of the carbonyl group. The entropy loss of the hydrogen bonding was dependent on the rotation freedom of the phenol group. The enthalpy of nine-membered intramolecular hydrogen bonding between carbonyl groups and phenolic hydroxyl groups of 2-arylmethylphenols was related to the electron-withdrawing ability of the substituents on the phenol and the basicity of the carbonyl group. The entropy loss was dependent on the rotation freedom of the phenol group.