5471-90-9

Basic information

• Product Name: Benzenesulfonamide, N-(4-hydroxyphenyl)-
• Synonyms: Benzenesulfonamide, N-(4-hydroxyphenyl)-
• CAS NO: 5471-90-9
• Molecular Formula: C₁₂H₁₁NO₃S
• Molecular Weight: 249.28564
• Mol File: 5471-90-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 156 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 443.2°Cat760mmHg
• Flash Point: 221.8°C
• Appearance: /
• Density: 1.408g/cm³
• Vapor Pressure: 1.82E-08mmHg at 25°C
• Refractive Index: 1.661
• PKA: 9.65±0.10(Predicted)
• CAS DataBase Reference: Benzenesulfonamide, N-(4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-(4-hydroxyphenyl)-(5471-90-9)
• EPA Substance Registry System: Benzenesulfonamide, N-(4-hydroxyphenyl)-(5471-90-9)

Safety Data

• Hazardous Substances Data: 5471-90-9(Hazardous Substances Data)

Usage

General Description

Benzenesulfonamide, N-(4-hydroxyphenyl)- is a chemical compound commonly known as 4-hydroxybenzenesulfonamide. It is a white to off-white powder with the molecular formula C12H11NO3S and a molecular weight of 253.29 g/mol. Benzenesulfonamide, N-(4-hydroxyphenyl)- is commonly used in the production of various pharmaceuticals and dyes. It acts as a carbonic anhydrase inhibitor and has been studied for its potential therapeutic effects in conditions such as glaucoma, epilepsy, and certain types of cancer. Additionally, it is also used as a precursor in organic synthesis and as a reagent in biochemical research. However,

InChI:InChI=1/C12H11NO3S/c14-11-8-6-10(7-9-11)13-17(15,16)12-4-2-1-3-5-12/h1-9,13-14H

Upstream product

• 123-30-8 4-amino-phenol 
• 98-09-9 benzenesulfonyl chloride 
• 1809-20-7 diisopropyl hydrogenphosphonate 
• 4056-56-8 N-(phenylsulfonyl)-1,4-benzoquinone monoimine 
• 868-85-9 Dimethyl phosphite 
• 150081-90-6 Dimethyl <2-hydroxy-5-phenyl>phosphonate 
• 368-43-4 phenylsulfonyl fluoride 

Downstream Products

• 4056-56-8 N-(phenylsulfonyl)-1,4-benzoquinone monoimine 
• 94042-55-4 2,6-bis(1-pyrrolidinylmethyl)-4-benzenesulfonamidophenol 
• 488-48-2 tetrabromobenzoquinone 
• 62638-01-1 N-benzenesulfonyl-2,6-dibromo-1,4-benzoquinone imine 
• 68374-96-9 N-phenylsulfonyl-2,3,6-trichloro-1,4-benzoquinone monoimine 
• 68375-07-5 N-phenylsulfonyl-2,3,6-trichloro-4-aminophenol 
• 4056-56-8 N-(4-Oxo-cyclohexa-2,5-dienylidene)-benzenesulfonamide 
• 36942-34-4 2-nitro-4-phenylsulfonamidophenol 
• 201993-42-2 N-(2,3,5,5,6-pentachloro-4-oxo-cyclohex-2-enylidene)-benzenesulfonamide 
• 330212-89-0 2,3,5,6-tetrachloro-4-phenylsulfonylaminophenol 
• 51767-43-2 N-phenylsulfonyl-2-chloro-4-aminophenol 
• 1056125-18-8 N-(4-nitrooxy-phenyl)-benzenesulfonamide 
• 51767-46-5 N-(3,5-dibromo-4-hydroxyphenyl)benzenesulfonamide 
• 1343489-19-9 C₁₈H₂₁N₃O₃S 

Relevant articles and documents

Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides

A method using calcium triflimide [Ca(NTf2)2] as a Lewis acid to activate sulfonyl fluorides toward nucleophilic addition with amines is described. The reaction converts a wide array of sterically and electronically diverse sulfonyl fluorides and amines into the corresponding sulfonamides in good yield.

Synthesis of 5-substituted 2,3-dihydrobenzofurans in a one-pot oxidation/cyclization reaction

Variously substituted 2,3-dihydrobenzofurans have been synthesized according to a sequential one-pot oxidation/cyclization procedure between para-aminophenol derivatives and an azadiene.

The novel behaviour of dialkyl phosphites toward 1,4-benzoquinone monoimines

Diethyl phosphite 2a reacts with N- (phenylsulfonyl) - 1,4 - benzoquinone monoimine 1a to give 1,4-diethyl [(2-hydroxy-5-[(phenylsulfonyl) amino ] phenyl] [sphosphonate 3a, diethyl (1-hydroxy - 4- [ ( phenylsulfonyl ) imino ] -2,5-cyclohexadiene )] phosph