5473-06-3Relevant articles and documents
Activated alumina ball catalyzed expeditious synthesis of 2-alkylbenzimidazoles with special emphasis on susceptible side chains possessing amide functionality
Ghosh, Sabari,Hudrlik, Anne,Mukhopadhyay, Chhanda
, p. 1737 - 1748 (2014/01/17)
A solvent- and chromatography-free, non-hazardous green protocol for the synthesis of 2-alkylbenzimidazoles has been developed under neutral conditions with water as the only by-product. Activated alumina balls, which have been shown previously to assist in amidation reaction, also catalyze very successfully the condensation of benzene-1,2-diamines with carboxylic acids to produce the corresponding benzimidazoles. This methodology is also applicable to susceptible side chains possessing an amide functionality.
Synthesis of α-chloroaldoxime O-methanesulfonates and their use in the synthesis of functionalized benzimidazoles
Yamamoto, Yuhei,Mizuno, Hiroo,Tsuritani, Takayuki,Mase, Toshiaki
supporting information; experimental part, p. 1394 - 1396 (2009/07/04)
Three different α-chloroaldoxime O-methanesulfonates were synthesized to investigate their chemical properties. The compounds were found to be stable and were able to be stored at ambient temperature without any precautions. The reactions with anilines we
Copper-catalyzed synthesis of benzimidazoles via cascade reactions of o-haloacetanilide derivatives with amidine hydrochlorides
Yang, Daoshan,Fu, Hua,Hu, Liming,Jiang, Yuyang,Zhao, Yufen
, p. 7841 - 7844 (2008/12/22)
(Chemical Equation Presented) We have developed an efficient method for the synthesis of benzimidazoles via cascade reactions of o-haloacetoanilide derivatives with amidine hydrochlorides. The protocol uses 10 mol % CuBr as the catalyst, CS2CO